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Formulation And Evaluation Of Perindopril Transmucosal Drug Delivery System | 7467
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Formulation and evaluation of perindopril transmucosal drug delivery system

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

P. Subhash Chandra Bose

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

Perindopril erbumine is an ACE inhibitor, used in treatment of hypertension. There are certain inherent drawbacks associated with this drug like shorter biological half life, undergo first pass metabolism, poor bioavailability. So this drug needs an alternative drug delivery system to conventional formulations. Perindopril buccoadhesive films were prepared by using HPMCK15M, Gantrez, Sodium alginate, polycarbophil mucoadhesive polymers. The physicochemical interaction between drug and polymers were investigated by DSC and FTIR. Prepared films were evaluated for their physicochemical properties, bioadhesive strength, in vitro dissolution studies, ex vivo permeation studies. The ex vivo permeation studies were carried out across pork buccal mucosa using Franz diffusion cell. Residual solvent concentration was determined by gas chromatography. The formulations showed satisfactory physicochemical characteristics. DSC and FTIR studies revealed no interaction between drug and polymer. All formulations showed sustained release over a period of 12 hours. By fitting the data into zero order, first order, Higuchi model and Peppas model, it was concluded that drug release from films followed Peppas model and the mechanism of the drug release was found to be non fickian diffusion. Stability studies of optimized formulation were carried out at 40?C/75% relative humidity. The formulation was found to be stable over a period of 3 months with respect to drug content and ex vivo permeation through porcine buccal membrane.
P. Subhash Chandra Bose has completed his M. Pharm from JSS College of Pharmacy, Mysore (Rajiv Gandhi University of Health Sciences). He is having 3 years industrial experience and 4 years experience in academics. He is doing Ph D in the area of ?Buccal mucoadhesive drug delivery systems? in centre for pharmaceutical sciences, JNTUH, Hyderabad. He has published 11 papers in reputed journals and also presented more than 40 papers in various national and international conferences/ seminars. He is Life Member of APTI.