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Perindopril erbumine is an ACE inhibitor, used in treatment of hypertension. There are certain inherent drawbacks associated
with this drug like shorter biological half life, undergo first pass metabolism, poor bioavailability. So this drug needs an
alternative drug delivery system to conventional formulations. Perindopril buccoadhesive films were prepared by using
HPMCK15M, Gantrez, Sodium alginate, polycarbophil mucoadhesive polymers. The physicochemical interaction between
drug and polymers were investigated by DSC and FTIR. Prepared films were evaluated for their physicochemical properties,
bioadhesive strength, in vitro dissolution studies, ex vivo permeation studies. The ex vivo permeation studies were carried out
across pork buccal mucosa using Franz diffusion cell. Residual solvent concentration was determined by gas chromatography.
The formulations showed satisfactory physicochemical characteristics. DSC and FTIR studies revealed no interaction between
drug and polymer. All formulations showed sustained release over a period of 12 hours. By fitting the data into zero order,
first order, Higuchi model and Peppas model, it was concluded that drug release from films followed Peppas model and the
mechanism of the drug release was found to be non fickian diffusion. Stability studies of optimized formulation were carried out
at 40?C/75% relative humidity. The formulation was found to be stable over a period of 3 months with respect to drug content and
ex vivo permeation through porcine buccal membrane.
P. Subhash Chandra Bose has completed his M. Pharm from JSS College of Pharmacy, Mysore (Rajiv Gandhi University of Health Sciences). He
is having 3 years industrial experience and 4 years experience in academics. He is doing Ph D in the area of ?Buccal mucoadhesive drug delivery
systems? in centre for pharmaceutical sciences, JNTUH, Hyderabad. He has published 11 papers in reputed journals and also presented more than
40 papers in various national and international conferences/ seminars. He is Life Member of APTI.
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