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Formulation And Evaluation Of PH-sensitive Nanoparticles For Intestinal - Site Specific Drug Delivery System | 7476
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Formulation and evaluation of pH-sensitive nanoparticles for intestinal - site specific drug delivery system

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

VNSK Varma

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

The objective of this study was to develop a novel pH sensitive nanoparticulate system for Intestinal- site specific drug delivery based on natural gums for the Intestinal ulcer application. Esomeprazole magnesium was used as a model drug. Guar gum is used as the polymer for preparation of pH sensitive nanoparticles. Thus formulated nanoparticles are dispersed in a Capsule. The size distribution of the prepared nanoparticles is measured. FT-IR and DSC were made to examine the compatibility between the drug and the polymer. The morphology of the nanoparticles is examined by SEM. Drug content of prepared nanoparticles is performed and the In-vitro dissolution of nanoparticles is evaluated.
VNSK Varma has done Bachelors in Pharmacy at NGSMIPS, Mangalore. He is presently pursuing M. Pharmacy in Pharmaceutics stream at JSS college of Pharmacy, JSS University Mysore. He has participated in several international conferences and seminars and made poster presentation in various international &conferences and seminars.
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