The objective of this study was to develop a novel pH sensitive nanoparticulate system for Intestinal- site specific drug delivery
based on natural gums for the Intestinal ulcer application. Esomeprazole magnesium was used as a model drug. Guar gum
is used as the polymer for preparation of pH sensitive nanoparticles. Thus formulated nanoparticles are dispersed in a Capsule.
The size distribution of the prepared nanoparticles is measured. FT-IR and DSC were made to examine the compatibility between
the drug and the polymer. The morphology of the nanoparticles is examined by SEM. Drug content of prepared nanoparticles is
performed and the In-vitro dissolution of nanoparticles is evaluated.
VNSK Varma has done Bachelors in Pharmacy at NGSMIPS, Mangalore. He is presently pursuing M. Pharmacy in Pharmaceutics stream at JSS
college of Pharmacy, JSS University Mysore. He has participated in several international conferences and seminars and made poster presentation
in various international &conferences and seminars.
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