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Formulation And In-vitro Evaluation Of Gastroretentive Drug Delivery System Containing Metronidazole | 7471
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Formulation and In-vitro evaluation of gastroretentive drug delivery system containing metronidazole

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Tapan Kumar Giri and Dulal Krishna Tripathi

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems for prolongation of the gastric residence times. The challenge to develop efficient gastroretentive dosage forms began following the discovery of Helicobacter pylori by Warren and Marshall. Helicobacter pylori lives deep within the gastric mucus layer and prolonged local application of drug is needed for sufficient to diffuse to the bacteria. Gastroretentive floating beads have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of metronidazole floating beads in order to increase the gastric retention time for the eradication of Helicobacter pylori. The beads were prepared by ionotropic gelation technique, using polymers solution such as sodium alginate and then dipping the dispersion into a solution of calcium chloride. Calcium alginate beads were formed. These beads were evaluated for entrapment efficiency, buoyancy, swelling and in vitro drug release. The prepared beads exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of drugs.