alexa Formulation Development And Evaluation Of Naturally Found Antioxidant
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference on Pharmacognosy, Phytochemistry & Natural Products
October 21-23, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Anuj G. Agrawal
Accepted Abstracts: Biochem & Pharmacol
DOI: 10.4172/2167-0501.S1.004
Abstract
Antioxidants are substances which counteract free radicals and prevent the damage caused by them. Coenzyme Q10 (CoQ 10 ) or ubiquinone is naturally found regenerable, bioenergetic, powerful, endogenous cellular antioxidant. It is a fat-soluble, pseudo-vitamin, composed of a long side chain containing ten isoprenoid units, hence the name CoQ 10 . It is a yellow-orange colored crystalline compound that can be synthesized de novo . It is available in the membranes of the Golgi, where it is present at an even higher concentration than in the mitochondria, as well as in plasma membranes. It acts as an electron and proton carrier in the mitochondrial respiratory chain activity as well as in Golgi and plasma membranes for NAD(P)H-oxidoreductase- dependent reactions such as in nitric oxide synthesis. It plays a crucial role in the production of adenosine triphosphate (ATP). It protects phospholipids and mitochondrial membrane proteins from peroxidation and protects DNA against the oxidative damage that accompanies lipid peroxidation. It has been demonstrated that CoQ 10 acts as a radical scavenger whose effects on improvement of cognitive functions has been shown. CoQ 10 functions as an antioxidant help to regenerate other antioxidants; influencing the stability, permeability and fludity of membranes; and stimulating cell growth and inhibiting cell death. CoQ 10 is also indispensible for the maintenance of the bioenergetics of skeletal and heart muscle. It is present in the body in both the reduced (ubiquinol) and oxidised (ubiquinone) forms. Its reduced form, ubiquinol is also an antioxidant. When cell membranes are oxidized, ubiquinol is the first antioxidant consumed. Moreover, the formation of oxidized lipids and the consumption of α-tocopherol are suppressed while ubiquinol is present. A deficiency in either its bioavailability or its biosynthesis disrupts normal cellular functions and can lead to one of several disease states. Dietary contributions of CoQ 10 are very small, but supplementation is effective in increasing plasma CoQ 10 levels. CoQ 10 has been reported to have a wide range of therapeutic effects, effective in numerous disorders and deficiency states and that supplementation has a favorable outcome. It is widely used as an anti-aging substance, as a drug for chronic heart failure, as a nutritional supplement, and in cosmetics. CoQ 10 is practically insoluble even in the presence of 5% sodium lauryl sulfate in water and poorly absorbed from the gastrointestinal tract. The slow absorption of CoQ 10 from the gastrointestinal tract is attributed to its high molecular weight and poor water solubility. Various solubilization strategies therefore, have been developed so as to increase its solubility. In this study, self emulsifying preconcentrate of CoQ 10 have been developed with the aim to increase its aqueous solubility. Optimization and assessment relied on solubility studies, emulsification efficiency, phase diagrams, dilution robustness, cloud point, particle size, and in vitro dissolution. Release studies demonstrated a significant increase in CoQ 10 release from the developed system compared to plain drug suspension.
Biography
Anuj G. Agrawal has completed his M.Pharm at the age of 23 years from University of Mumbai under the guidance of Prof. (Dr) R. R. Somani with outstanding academic record. Currently, he is a research scholar and has published 8 papers in various national & international journals and few more papers are in communication. A book chapter in his name is published in INTECH publisher. He has delivered oral and poster presentations at different national & international meetings which include the presentation at CSIR-National Physical Laboratory, New Delhi, University of Mumbai, Controlled Release Society-Indian Chapter, etc. He had received a travel grant from Gov. of India to attend the conference at Moscow, Russia.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords