alexa
Reach Us +447482877761
From Complete Catalogs To | 9356
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

16th World Congress on Structural Biology

Amsterdam, Netherlands
Share This Page

From complete catalogs to

International Conference on Integrative Biology Summit

Han Liang

Accepted Abstracts: J Comput Sci Syst Biol

DOI: 10.4172/0974-7230.S1.004

Abstract
Next-generation sequencing has become a revolutionary tool for cancer research. However, there is still a big gap between complete catalogues of genomic alternations identified from NGS studies and ?actionable? shortlists for further functional investigation. Using my two recent studies (RNA-seq in gastric cancer and exome-seq in endometrial cancer), I will discuss how to identify ?driver? genes underlying the tumorigenesis. In the first study, we performed a comprehensive analysis on the whole-transcriptome of gastric cancer, and developed a multilayer and integrative analytic framework for identifying potential therapeutic targets from RNA-seq data (Kim et al., Cancer Research 2012). In the second study, we developed an integrated systems-biology approach to identifying driver somatic mutations from whole-exome sequencing data, which combines bioinformatics prioritization, a high-throughput approach to generating mutants and high-through cell viability assays (Liang et al., Genome Research 2012).
Biography
Liang received Ph.D. training from the Quantitative and Computational Biology program at Princeton University in 2006. As a postdoctoral researcher, Dr. Liang completed three years of research on computational and evolutionary genomics at the University of Chicago. Currently, Dr. Liang is an Assistant Professor in the Department of Bioinformatics and Computational Biology at the University of Texas MD Anderson Cancer Center and he is also a faculty member in Graduate Program in Structural & Computational Biology & Molecular Biophysics in Baylor College of Medicine. His research interests include the analysis of next-generation sequencing data, the integration of cancer genomics data, microRNA regulation, and the evolutionary process of tumor cells.
Top