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Ganglion cell loss is the Major hispathological changes
on Alzheimer?s disease It has been
shown that Alzheimer?s disease (AD) patients expressed visual disorders, involved visual
acuity, stereopsis, colour vision, spatial contrast sensitivity, kinesthesia and ocular motility and
etc. All of those were attributed to the nerve degeneration of visual cortex as reported previously.
In addition, retina and optic nerve degeneration may also contribute to such disorders?
development in AD patients because the retina ganglion cells and their axons lost was clearly be
found in the AD patients at the postmortem stage. Clinical reports show that RNFL thickness is
thinner AD patients than that of controls, but there is no experimental evidence.
We studied the retinal histopathological changes by labeling populations of retinal ganglion
cells (RGCs) with horseradish peroxidase and HE staining on APP/PS1 transgenic mice aged
10 month. It was found that
the cells in retinal ganglion layer in model group are significantly
<0.01), cells have not obviously decreased in
Inner and outer nuclear layer
>0.05) on APP/PS1 transgenic mice. Our
results imply that
ganglion cell loss is the Major hispathological changes
on APP/PS1 transgenic mice. It comply with the clinical
studies about AD.
Dr. Yan Lu is the professor in the Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University. She has completed her MD. at the age
of 23 years from Tongji Medical University and Ph.D at the age of 29 years from Beijing Medical University. Her professional research includes glaucoma
and neuro-ophthalmology. She completed her observership in glaucoma at The New York Eye and Ear Infirmary in 2002. She has published more than
30 papers in reputed journals.
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