alexa Gastric Ulcer Healing Activity Of Zingiber Simaoense Y.Y. Qian Rhizome Ethanol Extract In Rats
ISSN: 2329-6836

Natural Products Chemistry & Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Conference and Exhibition on Marine Drugs and Natural Products
June 15-17, 2017 London, UK

Puongtip Kunanusorn, Ampai Panthong, Parirat Khonsung, Natthakarn Chiranthanut, Chaiyong Rujjanawate3 and Farida Laprasert
Chiang Mai University, Thailand
Mahidol University, Thailand
Mae Fah Luang University, Thailand
ScientificTracks Abstracts: Nat Prod Chem Res
DOI: 10.4172/2329-6836-C1-013
Zingiber simaoense Y.Y. Qian is a member in the Zingiberaceae family. In Thai Traditional Medicine, its rhizome has been used to relieve gastric disorders. The gastroprotective activity of Z. Simaoense Rhizome Ethanol Extract (ZSE) in experimental models of rats and some possible mechanisms to preserve gastric wall mucus have been reported. The aims of the present study were to find out the gastric healing activity of ZSE using acidified ethanol induced gastric ulcer model in rats, and to investigate more about the possible mechanisms of its gastroprotection using the methods of pretreatment with an inhibitor of Nitric Oxide (NO) synthase (NG-nitro-L-arginine methyl ester; L-NAME) and a Sulf Hydryl (SH) compound blocker (N-ethylmaleimide; NEM) in rats. The results showed that ZSE at the dose of 240 mg/kg could accelerate the gastric ulcer healing when observed on day 4 and 8, after ulcer induction. Pretreatment with L-NAME or NEM could inhibit gastroprotective activity of ZSE. In conclusion, the present study shows the gastric healing activity of ZSE, and the possible mechanisms of gastroprotection of ZSE may also involve its cytoprotective effect through gastric mucosal NO and SH compounds.

Puongtip Kunanusorn, PhD, is an Assistant Professor in the Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand. She has done her PhD from Chiang Mai University. She has published about 12 papers in many journals and has been serving as a reviewer of many well-known journals. Her research fields include pharmacological activities of medicinal plants, especially, anti-ulcer, analgesic, antipyretic and anti-inflammatory activities as well as toxicological studies (acute and sub-chronic toxicity studies).

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version