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|University of Bologna, Italy|
|Posters & Accepted Abstracts: J Clin Exp Cardiolog|
|Scientific interest in ischemic heart disease (IHD) in women has grown over the past two decades. A substantial amount of the
literature on this subject is centered on sex differences in clinical aspects of IHD. Many reports have documented sex-related
differences in presentation, risk profiles and outcomes among patients with IHD, particularly acute myocardial infarction.
Such differences have often been attributed to inequalities between men and women in the referral and treatment of IHD.
The determinants of sex differences in presentation are unclear. Some evidences are available as to why young, premenopausal
women paradoxically have a greater incidence of adverse outcomes after acute myocardial infarction than men, despite having
less-severe coronary artery disease. Other study underline possible difference in the coronary anatomy (women often have more
severe microvascular dysfunction), and in pathophysiological causes for chronic and acute presentation of IHD. Differential
treatment on the basis of patient sex continues are described. The extent to which such inequalities persist and whether they
reflect true disparity is under scrutiny. Additionally, much uncertainty surrounds possible sex-related differences in response
to cardiovascular therapies, partly because of a persistent lack of female-specific data from cardiovascular clinical trials.
1. Cenko E, Ricci B, Kedev S, Vasiljevic Z, Dorobantu M, Gustiene O, Knežević B, Miličić D, Dilic M, Manfrini O, Koller A, Badimon L and Bugiardini R (2016) Invasive versus conservative strategy in acute coronary syndromes: The paradox in women's outcomes. Int J Cardiol 222:1110-5.
2. Ricci B, Cenko E, Varotti E, Puddu PE and Manfrini O (2016) Atypical chest pain in ACS: A trap especially for women. Curr Pharm Des. 22:3877-84.
3. Vaccarino V1, Badimon L, Corti R, de Wit C, Dorobantu M, Manfrini O, Koller A, Pries A, Cenko E and Bugiardini R (2013) Presentation, management and outcomes of ischaemic heart disease in women. Nat Rev Cardiol 10:508-18.
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