alexa Generic Versus Brand Sofosbuvir-based Therapy: Safety And Efficacy- Real Life Data
ISSN: 2167-0889

Journal of Liver
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Hepatology
April 27-28, 2017 Dubai, UAE

Moutaz F Derbala, Elham Elsayad, Omr Hajelssedig, Aliaa Amer, Nazeeh Eldweik, Saad R Alkaabi, fuad I Pasic and Mohammed E Elbadri
Hamad Medical Corporation, Qatar
Posters & Accepted Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-012
Abstract
Background & Aim: Since the launch of the Qatar plan for HCV control by 2020, the expatriate HCV is a challenge, because of reduced access to innovative treatment caused by restrictions on drug reimbursement. The cost effective analysis, recognizes budget limitations for health care spending and seeks to maximize public health benefits within those budget constraints. In APASL 2016, we reported our preliminary analysis, which showed that low-cost generic antiviral drugs are as effective and safe as the more expensive brand-name drugs, in treating HCV. The aim is to assess the effectiveness and safety of generic versus brand medication, in 399 patients treated with sofosbuvir (SOF) based therapy. Method: This study is a single-centered cohort, retrospective, observational study, including 399 cases. All patients, who started Sof-based regimens, whether brand provided by Hamad center, Qatar, or generic brought by the patients, were included: 24 weeks of SOF/ribavirin (RBV) (22.3%), or 12 weeks of either, SOF/daclatasvir (DCV) (15.9%), SOF/simeprevir (SMV) (29.1%), or SOF/PegIFN/RBV (32.8%). Results: 33.1% were treated with brand and 66.9% were with the generic. GT1/GT4, were 57/399 (14.3%)/342/399 (85.7%). The overall response was 72% for generic compared to 87% for brand. In G4, the generic group had a lower response, both in cirrhotic and non-cirrhotic compared to the original, where SVR in non-cirrhotic was 80% and 88.5%, while in cirrhotic, 67.2% and 75%, respectively. In G1, SVR achieved 88.2% in cirrhotic and 94.1% in non-cirrhotic, with brand, compared to 75.0% and 100%, with generic. There was a significant increase in serotonin level in patients treated with generic compared to brand by weeks 2 and 24 (P = 0.029 and 0.025), but still within normal. The low response rate was seen in Sof/Rib group, 60.3%. Patients having Sof/Sim or Sof/Dac, are 4.46 and 5.32 times, more likely to achieve SVR-12 than other regimen. The patients received generic medication were more prone to adverse effects (P=0.29). 13.6% experienced adverse effects, including: 2 deaths have been reported on SOF/PR due to cardiac arrest and MI, HCC in 5 cases, decompansation in 2, other include anaemia and hyperbilirubenemia. Conclusion: Although response in generic is lower than brand, but still comparable, especially in Sof/Sim and Sof/Dac, regimens, with similar safety and tolerability. Generic drugs competition can dramatically reduce the price, but further study of long term safety, is needed. We suggest that Sof/Rib is not a proper option. The low price generic DAAS, ensures access to the new drugs, in low or moderate economic countries, and can afford an opportunity to join the initiative to achieve the ultimate elimination of HCV.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords