November 12-14, 2012 Hilton San Antonio Airport, USA
Volume 3 Issue 8
J Cell Sci Ther 2012
ISSN: 2157-7013 JCEST, an open access journal
November 12-14, 2012
World Congress on
Cell Science & Stem Cell Research
Richard G. Pestell, J Ce
l Sci Ther 2012, 3:8
Genetic determinants of breast cancer stem cells defined in mice
Richard G. Pestell
Kimmel Cancer Center, USA
reast cancer stem cells (BCSCs) constitute a subpopulation of tumor cells that express stem cell associated markers and
have a high capacity for tumor generation in vivo. Identification of BCSCs from tumor samples or breast cancer cell
lines has been based mainly on CD44+/CD24−/low or ALDH+ phenotypes. BCSCs isolation has allowed the analysis of the
molecular mechanisms involved in their origin, self-renewal, differentiation into tumor cells, resistance to radiation therapy
and chemotherapy, and invasiveness and metastatic ability. Molecular genetic analysis using knockout animals and inducible
transgenics has identified NF-B, c-Jun, p21CIP1, and Forkhead-like-protein Dach1 involvement in BCSC expansion and fate.
Clinical analyses of BCSCs in breast tumors have found a correlation between the proportion of BCSCs and poor prognosis.
Therefore, new therapies that specifically target BCSCs are an urgent need. We summarize recent evidence that partially explain
the biological characteristics of BCSCs
Richard G. Pestell, MB, BS, MD, PhD, MD (Hon. Causa), FACP, FRACP, MBA,
ctor, Kimmel Cancer Center, Vice President, Oncology Services,
Associate Dean, Cancer Programs, Chairman, Department of Cancer Biology
. Dr. Pestell received his MD (MBBS) from the University of Western
Australia and his PhD degree from the University of Melbourne. He undertook post doctoral and clinical training in Hematology/Oncology and
Endocrinology. As the single Australian recipient of the Royal Australian College of Physicians? Winthrop traveling scholar and Neil Hamilton Fairley
Scholar (1991-1994), he continued research at Harvard University and served as clinical fellow at Massachusetts General Hospital. Prior to his
current position at the Kimmel Cancer Center, Dr. Pestell was Director of the Lombardi Cancer Center, Associate Vice President of the Medical
Center at Georgetown University and Board member of the Georgetown University Hospital in Washington, DC.
Dr. Pestell has authored 388 original publications and book chapters and 187 published abstracts. His work is highly cited (~27,500 citations,
H-index:88). His papers have been published in prominent peer reviewed journals including Cell, Science, Nature Medicine, Molecular Cell and
EMBO J. In March 2002, he was ranked first in the world for increase in total scientific impact in biology and first in the world for biochemistry (ISI).
Dr. Pestell is funded as the Principal Investigator of six RO1 grants and Principal Investigator of the Kimmel Cancer Center CCSG grant.
Dr. Pestell has received a number of awards for his scientific discoveries in breast and prostate cancer, including the Harrison Award (highest award
of the Australian Endocrine Society), Fellow of the Royal Society of Medicine (UK), Doctor HonorisCausa, (University of Western Australia), elected
membership to the American Society of Clinical Investigators, the Irma T. Hirschl Weil Caulier Career Scientist Award, Diane Belfer Faculty Scholar
in Cancer Research, the Pfeiffer Award, and elected fellow to the American Association for the Advancement of Science. Dr. Pestell serves as a
reviewer for 11 funding agencies and has been an active member of NIH study sections (RO1, SPORES, Cancer Centers, Program projects). Dr.
Pestell has been a reviewer for 25 distinct scientific journals (currently an active editorial board member of seven journals) and has served on the
external advisory board of six NCI-designated cancer centers
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