alexa Genetic Markers That Predict Sensitivity Of Tumor Cells To Infection By Sendai Virus | 60884
ISSN: 2471-8556

Oncology & Cancer Case Reports
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15th World Congress on CANCER THERAPY, BIOMARKERS & CLINICAL RESEARCH

Anastasia O. Sosnovtseva, Dmitriy V. Kochetkov , Anastasia V. Lipatova, Darya A. Berzhitskaya and Andrey O. Zheltukhin
Pirogov Russian National Research Medical University, Russia
Posters & Accepted Abstracts: Oncol Cancer Case Rep
DOI: 10.4172/2471-8556.C1.003
Abstract
Oncolytic virotherapy is a new promising approach to treatment of various oncological diseases. At present Sendai Virus (SeV) is being actively investigated as a promising oncolytic drug. A number of studies have shown that recombinant and UV inactivated SeV is capable of effective elimination of tumor cells while sparing normal cells. SeV eradicates tumor cells mostly via induction of apoptosis, autophagy and necroptosis and, also, by induction of antitumor immunity. In this study we have demonstrated that primary lines derived from adenocarcinoma of prostate exhibit a differential sensitivity to SeV. It’s necessary to uncover genetic markers of interaction between malignant cells and viruses to enable a personalized approach to treatment and increase effectiveness of virotherapy. Quantitative PCR was used to estimate levels of expression of genes encoding RIG-1 like and Toll like receptors (TLR). It was demonstrated that levels of expression of TLR3 and TLR7 correlated with the degree of sensitivity of tumor cells from prostate gland to Sendai virus in a statistically significant way. Cell lines with the least expression of TLR3 and TLR7 exhibit the highest degree of sensitivity to that virus. A more detailed investigation of the mechanism of action of that viral strain will allow to uncover additional markers that would enable prediction of sensitivity of tumors from a particular patient to SeV and effectiveness of the oncolytic drug in the therapeutic regimen used with an utmost accuracy. Acknowledgements: our research was supported by Russian Ministry of Education grant RFMEFI60714X0067
Biography

Anastasia O. Sosnovtseva is a PhD-student at the Pirogov Russian National Research Medical University. Her research interests focus on oncolytic biotherapy.

Email: [email protected]

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