alexa Genetic Studies On Atopic Dermatitis: Role Of TNF-α And -β Genes Promoter Polymorphisms
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

10th Asia-Pacific Dermatology Conference
November 28-29, 2016 Melbourne, Australia

Ghaleb Bin Horaib, Fahad Al Harthi, Misbahul Arfin and Abdulrahman Al-Asmari
Prince Sultan Military Medical City, KSA
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.048
Abstract
The immunopathogenesis of atopic dermatitis (AD) is a very complex process that involves an array of molecules but it is evident that cytokines play a key role in the development of the clinical presentation of AD. The role of tumor necrosis factor (TNF) is a subject of recent interest in AD. This study was undertaken to determine the association of TNF-α (-308) and TNF-β (+252) gene polymorphisms with AD. TNF-α and-β genes were amplified in 104 AD patients and 211 matched controls using amplification refractory mutation systems (ARMS)-PCR methodology to determine the allele/genotype frequencies. The frequency of GA (TNF-308) genotype was significantly higher while the frequency of GG (TNF-α-308) genotype was lower in patients as compared to controls. It was inferred that genotype GA (TNF-α-308) was susceptible while genotype GG might be protective to AD. The frequency of GG at position +252 of intron 1 in TNF-β was significantly higher in patients as compared to controls while GA genotype was significantly lower in patients indicating that GG genotype of TNF- β (+ 252) might exert additive susceptibility to AD while GA might be refractory. In conclusion TNF-α (308) and TNF-β (+252) polymorphisms are significantly associated with the susceptibility to AD in Saudis and could be used as a genetic marker for disease mapping.
Biography

Ghaleb Bin Horaib has completed his PhD in Dermatological and Venereal Diseases from University of Fribourg, Germany. He did his MBBS from King Saud University of Riyadh, Saudi Arabia. He is the Deputy Director General of Medical Services in the Armed Forces, Ministry of Defense, Riyadh, Saudi Arabia. He has published 10 papers in reputed journals. He is associated with several ongoing projects on genetic basis of dermatological diseases in Saudis.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version