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Current psychiatric pharmacogenomic tests are now available to include many of the most commonly prescribed psychotropic
medications. The ability to personalize treatment demonstrates a substantial shift in practice from what worked for a ?typical?
patient to what now works for each ?individual? patient. Pharmacogenomics is the study of how genes affect the way a patient
responds to medication. Genomic differences can influence the efficacy of medications, can be the source of serious drug sideeffects,
and can increase the risk of drug-to-drug interactions. By having an evidence-based report of a patient?s genomic drug
suitability profile, a clinician can better understand how their specific patients may react to a medication.
The latest clinical and scientific findings to support clinicians and their patients in selecting medications and treating
neuropsychiatric disorders will be reviewed. This includes genetic polymorphisms that impact liver metabolism and mechanism
of action of psychiatric medications. Novel methods of reporting this laboratory information will also be reviewed. Recent
publications on clinical outcomes of patients receiving such testing will be briefly reviewed.
Pharmacogenomic treatment planning includes understanding of clinically important genetic variants affecting a patient?s
response to psychiatric medications. In today?s mental health care climate, it is critical that clinicians make informed, evidencebased
decisions about proper drug selection. Prescribing a medication regimen that is more likely to succeed because it is tailored
to an individual patient?s genetic profile can help the clinician better manage the patient?s disease and improve patient outcomes.
Debbie Thomas, EdD, MSN, APRN, PMHNP-BC, PMHCNS-BC completed her master?s degree in Psychiatric Nursing in 1992 from Indiana University
and her Doctorate in Education Leadership in 1997 from Spalding University. She has worked in the field of nursing for over 30 years and psychiatric
mental health for over 25 years. Currently, she is the director of the graduate psychiatric nurse practitioner program at the University of Louisville
School of Nursing. She is the owner of Crescent Hill Psychiatric Services in Louisville, KY. She was most recently recognized by the International
Society of Psychiatric Nurses as the International Psychiatric Educator of the Year for 2012. Additionally, she received the Marcia J. Hern award for
teaching in 2013. She is an active member in the leadership of the American Psychiatric Nursing Association (APNA) and the International Society of
Psychiatric Nurses (ISPN). She presents on a variety of PMH topics annually at the national and/or international level. She is a manuscript reviewer
for the Journal of Psychiatric Nursing. She has conducted research and published on a variety of psychiatric topics. She is a recognized professional
speaker and leader in cutting edge psychiatric nursing practice and education.
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