Genotoxic Risk For Workers From S?o Paulo City, Brazil, Due To Occupational Exposure To Traffic Air Pollution | 16592
Journal of Clinical & Experimental Cardiology
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The goal of this study was to evaluate the genotoxic potential effects of air pollution (PM2.5) generated by traffic on exposed
individuals, during work, from S?o Paulo City, Brazil. The study involved 58 male workers from S?o Paulo City: 43 are taxi
drivers and traffic controllers, that characterize the downtown?s environment and 15 workers from the Forest Institute, that
characterize the outskirt of the City, called ?city green belt?.
Each participant used a Personal Environmental Monitoring Sampler (PEMS) designed by our team, to measure PM 2.5
particles mass. The PEMS were operated continuously at 4-LPM over 24-hour. Particles were collected on a policarbonate
membrane filter. The frequency of Micronucleus (MN) in exfoliated oral mucosa cells and peripheral blood lymphocytes of
the voluntaries was also determined.
The exposure to PM2.5 was higher in the downtown workers than in the outskirt workers (mean?SE, 39.2?2.1 and
22.9?1.4, respectively; p<0.001, ANOVA). The frequency of MN found in both, downtown and outskirt workers, was high
either in lymphocyte (mean?SD, 7.8?0.4 and 4.6?0.5, respectively; p<0.001, ANOVA) as in oral mucosa (mean?SE, 16.1?0.7
and 6.6?0.4, respectively; p<0.001, ANOVA).
In conclusion, the MN has served both as biomarkers of genetic damage, as indicators to monitoring occupational health.
These markers may have applicability in assessing genotoxicity in exposed individuals due to their high reliability. Therefore, it
should be accepted and used by the government for the benefit of its citizen?s occupational health
Monica V. Marquezini is a Scientific Researcher at Pro-Blood Foundation of Blood Center of S?o Paulo. She is also part of Experimental Air Pollution Laboratory,
Medical School of University of S?o Paulo, Brazil, since 2010. Marquezini is an Expert in Cellular and Molecular Biology with cell surface proteins studies and
extracellular matrix research. And she is Teacher of Cell and Molecular Biology themes at different graduation careers, Post-graduation advisor, Coordinator of
specialization courses and National and International Projects. She did her Ph.D. in Science from the Federal University of S?o Paulo-School of Medicine during
1996 and M.Sc. in Molecular Biology. She graduated in Biological Sciences Medical Modality from the University Methodist Piracicaba, Brazil (1983).
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