alexa Glioblastoma Multiforme. An Advanced Analysis Of 153 Patients And Review Of The Literature
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

14th World Congress on Neurology and Neurological Disorders
July 17-18, 2017 Chicago, USA

Mohammad Sadegh Nikdad, Farshid Farhan, Milad Shafizadeh, Atefeh Sadat Mirmohseni, Mohsen Afarideh, Shabnam Asadi Komeleh, Marzieh Lashkari, Morsaleh Ganji, Alireza Ghajar, Saeed Shafiei, Yalda Shafizadeh4, Ali Kazemian and Hooshang Saberi
Neurosurgery Research Center, Tehran University of Medical Sciences, Iran
Department of Neurosurgery, Tehran University of Medical Sciences, Iran
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Iran
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, USA
Correspondence to: Farshid Farhan MD, Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Iran
ScientificTracks Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562-C1-055
Abstract
Glioblastoma multiforme (GBM) is an aggressive primary tumor with frequent recurrences that leaves patients with a short survival time and a low quality of life. The aim of this study was to review prognostic factors in patients with glioblastoma multiforme. The focus of this retrospective study was a group of 153 patients with supratentorial GBM tumors, who were admitted in a tertiarycare referral academic center from 2005 to 2013. Factors associated with survival and local recurrence were assessed using the hazard ratio (HR) function of Cox proportional hazards regression and neural network analysis. Of the 153 patients, 99 patients (64.7%) were male. The average age of patients was 55.69 ± 15.10 years. The median overall survival (OS) and progression-free survival (PFS) were 14.0 and 7.10 months, respectively. In the multivariate analysis, age (HR =2.939, P <0.001), operative method (HR =7.416, P <0.001), temozolomide (TMZ, HR =11.723, P < 0.001), lomustine (CCNU, HR= 8.139, P <0.001), occipital lobe involvement (HR =3.088, P <0.001) and Karnofsky Performance Status (KPS, HR=4.831, P <0.001) were shown to be significantly associated with a higher OS rate. Furthermore, higher KPS (HR=7.292, P <0.001), operative method (HR =0.493, P =0.005), the use of CCNU (HR=2.047, P =0.003) and resection vs. chemotherapy (HR =0.171, P <0.001) were the significant factors associated with local recurrence of tumor. Our findings suggest that the use of CCNU and TMZ, operative method and higher KPS readings are associated with both higher survival and lower local recurrence rates.
Biography

Mohammad Sadegh Nikdad is currently working in the department of neurosurgery at Tehran University of Medical Sciences, Iran. He has published several original research papers in reputed and peer reviewed journals and also participated into several scientific meetings.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords