Gonad tissue xenotransplantation a potential aproache to fertility preservation

International Conference and Exhibition on Tissue Preservation & Bio-banking

July 20-22, 2015 Barcelona, Spain

Paulo Henrique Almeida Campos-Junior

Posters-Accepted Abstracts: J Tissue Sci Eng

Abstract :

Gonad tissue xenograft is a powerful approach developed in the last decade. In this technique, small fragments of testis or ovarian cortex from different mammalian donor species, are placed subcutaneously under the back skin of an immunodeficient mouse, where they respond to the rodent gonadotropins, initiating and leading to complete spermatogenesis. As expected, this approach became an attractive strategy to recapitulate and study gonad development in non-rodent species and, among several other important applications, could be used to preserve the germplasm of young individuals in which sperm collection is not an option or to preserve the fertility of aged womens. In this scenario, our group have been developed some studies using theses techniques. In relation to the testis xenograft, recently we showed the production of fertile sperm from collared peccary under the back skin os immunodeficient mice. Aditionally we are developing interesting studies aming preserve the female fertility using ovarian cortex tissue xenograft.