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Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen
species may play a key role in the development of lung fibrosis. The present work studied the effect of green tea extract on
bleomycin–induced lung fibrosis in rats. Animals were divided into three groups: (1) saline control group; (2) bleomycin group in
which rats were injected with bleomycin (15 mg/kg, i.p.) three times a week for four weeks; (3) bleomycin and green tea group in
which green tea extract was given to rats (100 mg/kg/day, p.o) a week prior to bleomycin and daily during bleomycin injections for 4
weeks until the end of the experiment. Bleomycin–induced pulmonary injury and lung fibrosis that was indicated by increased lung
hydroxyproline content, elevated nitric oxide synthase, Myeoloperoxidase (MPO), Platelet Activating Factor (PAF), Tumor Necrosis
Factor α (TNF-α ), Transforming Growth Factor 1β (TGF1β) and Angiotensin Converting Enzyme (ACE) activity in lung tissues.
On the other hand, bleomycin induced a reduction in reduced Glutathione concentration (GSH). Moreover, bleomycin resulted in
severe histological changes in lung tissues revealed as lymphocytes and neutrophils infiltration, increased collagen deposition and
fibrosis. Co-administration of bleomycin and green tea extract reduced bleomycin–induced lung injury as evaluated by the significant
reduction in hydroxyproline content, nitric oxide synthase activity, levels of MPO, PAF & TNF-α & ACE in lung tissues. Furthermore,
green tea extracts ameliorated bleomycin– induced reduction in GSH concentration. Finally, histological evidences supported the
ability of green tea extract to attenuate bleomycin–induced lung fibrosis and consolidation. Thus, the findings of the present study
provide that green tea may serve as a novel target for potential therapeutic treatment of lung fibrosis.
Azza El-Medany completed her PhD from Alexandria University and Postdoctoral studies from Alexandria University College of Medicine. She is a Professor of Pharmacology & Vice Head of Department of Pharmacology, College of Medicine , KSU. She published more than 40 papers in the areas of GIT, CVS, natural products & toxicological researches in reputed journals and serving as a Member of a number of professional bodies, was a Speaker in a number of international conferences like the ones in Singapore, Japan, Brazil & USA. She is a recipient of Special Awards in scientific research & teaching.