alexa Hair Follicle Regeneration From Human Pluripotent Stem Cells
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

11th Global Dermatologists Congress
November 14-15, 2016 Dubai, UAE

Michel Ragy Hanna, Yang Liu, Hasan El-Fakahany, Walid Medhat, Hamza Abdel-Raouf and Evan Y Snyder
Minia University, Egypt
Sanford-Burnham-Prebys Medical Discovery Institute, USA
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.045
Abstract
Hair follicle (HF) morphogenesis and regeneration depend on intensive and reciprocal interactions between epithelial and mesenchymal components. Currently, attempts to regenerate HFs depend on combining receptive epithelial and trichogenic dermal mesenchymal components and grafting them into an in vivo environment. Unfortunately human HF bulge stem cells (BSCs) are not suitable for this purpose because the isolation and propagation of human HF BSCs for tissue engineering purposes remains a challenge. Here we developed a strategy to differentiate human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) into CD200+/ITGA6+ BSCs that can reconstitute the epithelial components of the HF. Importantly, co-transplantation of hESCs or hiPSC-derived CD200+/ITGA6+ cells with trichogenic mice dermal cells into immunodeficient nude mice resulted in HF formation. Histological analysis revealed that the obtained HFs posses all HF lineages including the hair shaft and the inner and outer root sheaths. Human HF stem cell markers such as keratin-15 were detected in reconstituted HFs. The human origin of the epithelial cells in the new HFs was confirmed by positive reactivity for human-specific nuclear antigen. In this context derivation of functional HF BSCs capable of inducing a new hair formation suggest a major step toward developing cell-based treatments for alopecia.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords