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Recent studies demonstrated that host/virus interactions are crucial tools in progression of high percentages of cases
infected by HCV. There are very strong evidences that virus persistence and transition from acute to chronic phase of the infection
are mainly conditioned by the kind of host?s immune responses.
Researches unresolved problems:
Chimpanzees are the only alternative model of human infection. Thus, human cellular lines and
small animal models may be somehow not sufficient to account for the study of the whole host/virus interactions in humans, to
predict outcomes, to explain interactive mechanisms and try therapeutic vaccines, since studies mostly lack the reproduction of the
micro environment which the virus is exposed to. HCV high mutation rate, to modify or to avoid reactions, is considered the main
active strategy which the host seems passively undergo to.
Teleological Host Reactions Evidences:
Facing the main problems, when infected, i.e. clearing the virus in due time, otherwise
balancing the infection, avoiding autoimmunity induction and uncontrolled cells production (to do not determine other dangerous
outcomes), the host punctually has to choose the appropriate reactions, maintaining at the same time the control of both virus
diffusion and his own safety. Main disposable mechanisms are here briefly exposed and connected to their function and finality on
the host?s side.
Consequences on immune therapies and therapeutic vaccines:
Till now the only positive results are gained by a poorly tolerated
therapy (with more or less 50% failures) and postulated potentially dangerous modifications of immune responses. Overall, it seems
that any helpful intervention has more chances to be efficacious during the early phase of the infection, before the anergic choice by
the host, that may lead to a tolerance status difficult to remove, is primed or established. This implies the need of both a precocious
diagnosis and precocious therapy, being the main factor actually hampering therapeutic vaccines attempts. Furthermore, it seems
that one therapeutic approach alone cannot resolve the dramatic complexity of virus/host/tumor interactions. Thus, combinations of
single approaches are needed unless significant improvements in knowledge and validation of new hypotheses will change the rule.
Salvatore Marco Criscione, male, physician, graduated in medicine from University la Sapienza Rome in 1970. He worked for the University of
Rome ?la Sapienza? (1970-1987) as : Assistant in Internal Medicine (1970-1973); Assistant in Paediatric Clinic (1973-1980); Associate Professor of
Paediatrics (1980-1987). He became Full Professor of Paediatrics (1988) in the University of L?Aquila (Italy) - Department of Experimental Medicine
and Chief of the Academic Paediatric Area (including: Paediatric Clinic, Neonatology, Infantile Neuropsichiatry, Paediatric Surgery)
Specialistic graduations: Endocrinology and Metabolic Diseases (1973); Paediatrics (1976); Fellowship in Allergy & Immunology (1977) His scientific
main works deal with: Hypertension, Electron Mycroscope Studies on Liver, Seminal Liquid. In Children: Epidemiology of Pulmonary Diseases,
Allergy, Coeliac Disease, Thyroid, Respiratory Viruses Infections, Host/Virus interactions. He was the only Italian partner of a European Project: AIM
(Advanced Informatics in Medicine) on Quality Assurance in Pediatric Care and past member of APA (Ambulatory Pediatric Association- USA). Now
retired (from 2004).
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