Hepatitis B vaccine and murine schistosomiasis
3rd World Conference on Parasitology & Pathogenesis
July 12-13, 2017 Chicago, USA

Sonia R Allam, Ossama N Mohamed, Safeya M Ali, Maha M Eissa and Lobna A El-Zawawy

Alexandria University, Egypt

Posters & Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Statement of the Problem: In tropical countries, the effect of some infections on the immunological response to vaccination regimens should be considered. Schistosomiasis which is a major health problem in these areas, results in a suppressed immune response to a variety of antigens. Conversely, some killed bacteria or viruses have been reported to elicit protective effect against schistosomal infection. The aim of the present study was to investigate the influence of schistosomal immunosuppression on the antibody response to hepatitis vaccine and to study if the vaccine has any protective effect on experimental Schistosoma mansoni infection. Methodology & Theoretical Orientation: Swiss strain albino mice were vaccinated with hepatitis vaccine at varying intervals in relation to S. mansoni infection. Assessment of both; effect of S. mansoni infection on the immune response to hepatitis B vaccine and the possible protective effect of the vaccine on S. mansoni infection was carried out. Findings: The present study revealed that S. mansoni infection reduced the serum antibody level against hepatitis B vaccine in almost all experimental groups. Parasitological and histopathological findings showed significant protection against S. mansoni infection. Conclusion & Significance: Interrelationship between Schistosoma infection and hepatitis B vaccine was related to duration of Schistosoma infection. When Schistosoma was initiated before or simultaneously with hepatitis B vaccine, the compromising effect of Schistosoma predominated while if infection was acquired after immunization the stimulant effect of the vaccine took the upper hand. In order to reduce virus B infections in schistosomiasis endemic areas public health officials should evaluate a policy for regulation of hepatitis B vaccine booster immunization to enhance the population immunity against hepatitis B infection.

Biography :

Email: Sonia_allam@hotmail.com