alexa Herbal A Ameliorates Experimental Autoimmune Encephalomyelitis By Suppressing T Cell And Macrophage
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

14th World Congress on Neurology and Neurological Disorders
July 17-18, 2017 Chicago, USA

Wen-Ting Li and Jian-Gang Shen
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
Posters & Accepted Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562-C1-056
Abstract
Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) without effective treatment or medication so far. Current medication cannot fundamentally alter the progressive disease course or reverse of existing deficits and long-term disability in MS patients. Herbal A, a kind of Traditional Chinese Medicine (TCM), has been widely used for the treatment of immune system diseases in clinical application and has a better therapeutic effect. However, the relevant report about Herbal A as a therapy for MS is rare. In this study, we demonstrated that Herbal A treatment effectively ameliorated clinical disease severity with reduced spinal cord inflammation and demyelination in experimental autoimmune encephalomyelitis (EAE), a laboratory murine model of MS. Furthermore, the underlying mechanism of herbal A-induced effects was also investigated. Herbal A treatment alleviated encephalitogenic T cells and actived macrophages infiltrating into CNS through JanusKinase/Signal Transducer and Activator of Transcription (Jak/STAT) and Nuclear factor- κ B (NF- κ B) signaling pathways as well as reduction of reactive free radicals. Together, these results indicate that herbal A exerts potent anti-inflammatory effects through selective modulation of T cells and macrophages by targeting critical signaling pathways, which could be a promising therapeutic agent for the treatment of neuroinflammatory diseases.
Biography

Wenting Li has her expertise in isolation, identification and characterization of bioactive compounds in Traditional Chinese Medicine(TCM). She also focuses on evaluating bioactivities of chemical compounds, especially in the aspect of autoimmune disease..

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords