alexa
Reach Us +1-217-403-9671
High-Quality Combinatorial Approaches For Protein Discovery And Development | 8174
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

High-Quality combinatorial approaches for protein discovery and development

International Conference and Exhibition on Biowaivers & Biosimilars

Luke H. Bradley

ScientificTracks Abstracts: J Bioequiv Availab

DOI: 10.4172/0975-0851.S1.002

Abstract
With the emergence of recombinant technology, molecular biology, drug formulation and delivery; proteins are increasingly being developed and utilized as biotherapeutics to treat a wide-array of diseases. However for the widespread use of proteins for these applications, often we are limited by their evolved physical and functional properties, as well as production costs. To overcome these limitations, in order to expedite discovery and streamline development, technologies are needed which successfully incorporate large collections of synthetic sequences into robust protein structural scaffolds. Here we present the application of high-quality protein library design approaches to generate large synthetic collections of soluble and highly expressible protein-binding proteins, free of incorporation of deleterious genotypic frameshifts and deletions, to facilitate the identification of proteins with novel and specific binding to non-physiological, and medically-relevant binding targets. Collectively, these findings support that high-quality combinatorial approaches are a platform technology for easily and productively generating large collections of functionally-rich proteins for emerging biotherapeutic applications.
Biography
Luke H. Bradley completed his Ph.D. in biochemistry from Ohio State University. Following a postdoctoral fellowship at Princeton University, Dr. Bradley joined the faculty at the University of Kentucky College of Medicine as an Assistant Professor of Anatomy and Neurobiology. He is also affiliated with the University of Kentucky?s Center of Structural Biology and the department of Molecular and Cellular Biochemistry. Dr. Bradley?s research interests include the discovery and development of novel, synthetic peptide- and protein-based molecular platforms for downstream bioapplications and Parkinson?s disease therapeutics
Top