This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
With the emergence of recombinant technology, molecular biology, drug formulation and delivery; proteins are increasingly
being developed and utilized as biotherapeutics to treat a wide-array of diseases. However for the widespread use of
proteins for these applications, often we are limited by their evolved physical and functional properties, as well as production
costs. To overcome these limitations, in order to expedite discovery and streamline development, technologies are needed which
successfully incorporate large collections of synthetic sequences into robust protein structural scaffolds. Here we present the
application of high-quality protein library design approaches to generate large synthetic collections of soluble and highly expressible
protein-binding proteins, free of incorporation of deleterious genotypic frameshifts and deletions, to facilitate the identification
of proteins with novel and specific binding to non-physiological, and medically-relevant binding targets. Collectively, these
findings support that high-quality combinatorial approaches are a platform technology for easily and productively generating
large collections of functionally-rich proteins for emerging biotherapeutic applications.
Luke H. Bradley completed his Ph.D. in biochemistry from Ohio State University. Following a postdoctoral fellowship at Princeton University, Dr.
Bradley joined the faculty at the University of Kentucky College of Medicine as an Assistant Professor of Anatomy and Neurobiology. He is also
affiliated with the University of Kentucky?s Center of Structural Biology and the department of Molecular and Cellular Biochemistry. Dr. Bradley?s
research interests include the discovery and development of novel, synthetic peptide- and protein-based molecular platforms for downstream
bioapplications and Parkinson?s disease therapeutics
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals