alexa HIV-1 Gp120 And Methamphetamine-Mediated Toxicity In The Brain
ISSN: 2161-0517

Virology & Mycology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

9th International Virology Congress and Expo
March 13-14, 2017 London, UK

Anil Kumar
University of Missouri, USA
ScientificTracks Abstracts: Virol Mycol
DOI: 10.4172/2161-0517.C1.017
HIV associated neurocognitive disorder (HAND) remains a major concern for patients infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased expression of various proinflammatory cytokines. Additionally, it has been well documented that various drugs of abuse can exacerbate HAND, but the mechanism by which this occurs is still poorly understood. The present study was based on the central hypothesis that HIV-1 gp120 and methamphetamine (MA) interact with each other to increase the cytotoxicity in the astrocytes, which is mediated via induction of various pro-inflammatory cytokines/chemokines and oxidative stress. In order to test these hypothesis four different studies were designed. We also investigated the mechanism(s) and pathways involved in the functional interaction between gp120 and MA. Furthermore, in order to understand the functional implications of the interaction between MA and gp120, we examined the combined effect of MA and gp120 to produce oxidative stress and apoptotic cell death. We also studies the involvement of ER stress in the HIV-1 gp120-mediated cell death in the astrocytes. We investigated the role of gp120 in the cytokine production in astrocytes. SVGA astrocytes and human fetal astrocytes were either transfected with a plasmid coding gp120 or treated with recombinant gp120 protein and the expression levels of various cytokines at RNA and protein levels were measured. In order to better explain the role of gp120 in the induction of proinflammatory cytokines/chemokines, 3 major and highly induced cytokines/chemokines were screened and further mechanistic studies were aimed with these 3 cytokines/chemokines. We investigated the role of NF- κB pathway in the transcriptional regulation followed by studies to identify molecular mechanisms. In conclusion, we have shown that both MA and gp120 independently and in combination increased the production of proinflammatory cytokine/chemokines via different pathways. The functional consequences for the interaction between gp120 and MA led to oxidative stress and ER stress, which resulted in apoptotic cell death in astrocytes. Thus, our current studies provide the evidence and underlying mechanisms for the neurotoxic potential of HIV protein, gp120 and substance of abuse, methamphetamine.

Anil Kumar completed his education in Kanpur University, Kanpur, India, 1987. He is currently working as an Chair and Professor, University of Missouri-Kansas City School of Pharmacy Division of Pharmacology. He is current Research Interests on Effect of drug and alcohol abuse on pathogenesis of AIDS, Identification of target of immune responses in HIV-1 during natural infection, Compartmentalization of HIV during natural infection, Vaccine approaches in monkey model of AIDS.


image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version