alexa Hole Transport In Oxidized DNA: An Integrated Approach Based On Electrochemistry, Spectroscopy And Quantum Chemistry
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Electrochemistry
July 10-11, 2017 Berlin, Germany

Amedeo Capobianco
University of Salerno, Italy
ScientificTracks Abstracts: J Phys Chem Biophys
DOI: 10.4172/2161-0398-C1-019
Abstract
Singly ionized DNA exhibits long range hole transport (HT) covering distances up to 200 Å. Hole transport has great biochemical and technological relevance, as it controls the site distribution of the oxidative damage in DNA and makes DNA a potential conduit for nano-electronics, used both as template and as active component. Different mechanisms for the hole transport have been invoked so far i.e., ion gated transport, thermal activated hopping, and super-exchange among others. Independent of the kinetic mechanism, the hole transfer in oxidized DNA is modulated by the complex mosaic of low-lying electronic states, whose accessibility depends on the effective in-situ hole energies of nucleobases and the electronic couplings between interacting nucleobases. The hole energies for adenine (A) and guanine sites were previously quantified by using voltammetry, the influence of hydrogen bonds on the oxidation potential was also determined. Information for cytosine oxidation was inferred by spectroelectrochemistry experiments. Here we have focused our attention on electronic coupling parameters. The latter have been estimated by the lowering of the oxidation potential observed for DNA oligonucleotides containing an increasing number of stacked homo-purine nucleobases. Voltammetric data were interpreted in terms of the two state model (Figure 1). Experimental results were further confirmed by theoretical computations carried out at the full quantum level for single and double stranded oligonucleotides including sugarphosphate backbone and solvation. The observed lowering of the oxidation potential for single stranded oligonucleotides containing an increasing number of adjacent adenines amounts to ca 0.3 V for the AA step, in good agreement with theoretical predictions. That result suggests that adenine tracts give rise to delocalized hole domains (Figure 1), greatly facilitating hole transport in DNA. Although, stacking interactions are found to be less effective in stabilizing the positive charge on adjacent guanines inside a strand, our results confirm that guanine tracts constitute a very efficient trap for the hole.
Biography

Amedeo Capobianco earned his PhD in 2008 from the University of Salerno, where he is currently working as an Assistant Professor. His current research interests include the theoretical treatment of charge transport phenomena in biochemical systems and in organic materials.

Email: acapobianco@unisa.it

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords