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Aims:To investigate the levels of homocysteine (Hyc) and hydroxyproline (Hyp) in aqueous
humor and plasma of human eyes with primary open-angle glaucoma (POAG) and to correlate
their concentrations with the severity of glaucoma.
: Eighty five patients with POAG and thirty five patients with senile cataract (control
group) were enrolled in the study prospectively. Aqueous humor samples were obtained by
paracentesis from glaucoma and cataract patients who were undergoing elective surgery. Aqueous
humor and corresponding plasma samples were analyzed for Hyc and Hyp concentrations by
high performance liquid chromatography and spectrometrically respectively.
Hyc and Hyp levels were significantly higher in aqueous humor of POAG patients with
respect to the comparative group of cataract patients (P<0.001). No significant difference in the levels of Hyc and Hyp in plasma
of POAG and cataract patients. A positive correlation was found between Hyc and Hyp in aqueous humor of POAG patients
(P<0.001). No significant correlation was found between either Hyc or Hyp levels and the severity of visual field loss.
Increased levels of aqueous humor Hyc and Hyp may be associated with POAG. In addition, Hyc and Hyp may be
useful proteins levels in aqueous humor of POAG patients as a consequence of glaucomatous damage.
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