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The association between Plasma homocysteine concentration and metabolic parameters were evaluated in sixty cases of Type
2 Diabetes Mellitus patients (30 with cardiovascular complications and another 30 without cardiovascular complications).
Cases were randomly selected from patients attending Diabetic clinic and Medicine Ward, RIMS, Imphal. Another thirty age and
sex matched normal volunteers were taken as control. Plasma Homocysteine was estimated by ELISA (Axis-Shield Diagnostic,
UK). Statistical analysis was done to find outthe co-relation using multiple linear regression and ANNOVA. The mean �SD serum
homocysteine levels of the T2DM patient with cardiovascular complications and T2DM without cardiovascular complications
were found to be significantly higher than the control subjects. Mean�SD of homocysteine level was 27.20�6.02 mmol/l and
18.03�4.6 mmol/l in the two sub groups of the cases compared to 9.36�1.70 mmol/l in the controls. Homocysteine is positively
co-related with total cholesterol (r=0.121, p<0.05) and negatively co-related with HDL level (r=-0.166, p<0.05). A positive
correlation is found between the serum homocysteine level and blood pressure. Homocysteine and Dyslipidaemia increase
the cardiovascular risk significantly in T2DM. Homocysteine may be estimated as a prognostic indicator to assess the risk of
developing cardiovascular complications.
Chanchal Lamabam has completed her MBBS in 2005 from Regional Institute of Medical Sciences, Manipur and pursuing postgraduate in Biochemistry Department, RIMS since 2011
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