alexa How Structural Biology Can Help To Understand Antibiotic Mechanism And Resistance And Contribute To Discovery New Anti-tuberculosis Drugs
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Congress on Bacteriology & Infectious Diseases
November 17-19, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Marcio Vinicius Bertacine Dias
Accepted Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.008
Abstract
Structural biology is one of the techniques that can be used to predict the interaction between proteins, such as enzymes and substrates. We also can use crystallography to design new inhibitors based in structure. One of the approaches which researches groups and pharmaceutical companies have been used the crystallography and its association with other biophysical techniques to design new drugs call fragment based drug discovery (FBDD). We have used this approach to identify new series of compounds that inhibits the enzyme dihydrofolate reductase (DHFR) from M. tuberculosis. We also have used crystallography to understand the reason why antifolate drugs; such as trimethoprim, which is a classical dihydrofolate reductase, does not have activity against Mycobacterium tuberculosis. We have identified residues of active site of DHFR which may decrease the affinity to trimethoprim and other antifolate drugs. We also describe a completely new structural movement of domains of DHFR which disturbs the interaction between DHFR and inhibitors. Based on this founds, we are applying the technique FBDD to identify compounds that might be leads in the development of new series of antibiotics against M. tuberculosis. Initially we have identified leads by biophysical methods and the crystallographic structures predicting its interactions were determined. In this talk we will show data about all our research on the enzyme DHFR from M. tuberculosis, including mechanism of low affinity effect of antifolate drugs until the start point of design of new inhibitors.
Biography
Marcio Vinicius Bertacine Dias has completed his PhD at the age of 28 years from University of State of S?o Paulo- Brazil; and postdoctoral studies from University of Cambridge-UK, Department of Biochemistry. He is a Young Research Fellow at Laborat?rio Nacional de Bioci?ncias, CNPEM, a Brazil Federal Institute of Research. He has published about 20 papers in reputed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]nline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords