alexa Human Clinical Trial Of SAV001 Prophylactic HIV Vaccine And A New Strategy For The Development Of Therapeutic HIV Vaccine
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Vaccines & Vaccination
September 24-26, 2014 Valencia Convention Centre, Spain

Chil Yong Kang
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.020
Abstract
V accination is the most powerful and cost-effective approach for prevention of infectious diseases. Several approaches have been utilized to develop a vaccine against HIV/AIDS. These include a surface protein-based vaccine (AIDSVAX by VaxGen), a recombinant Human Adenovirus type 5-based vaccine (STEP trial by Merck), a recombinant canary poxvirus based vaccine (RV144 trial by Sanofi), and a combination of a DNA-based vaccine with recombinant adenovirus-based vaccine (HVTN 505 trial by USNIAID). Unfortunately, all of these vaccines were proven to be ineffective to prevent HIV infection. WHO reports ?Since the beginning of the epidemic, over 70 million people have been infected with the HIV and about 36 million people have died of AIDS. Globally, 35 million people were living with HIV at the end of 2013.? We have developed the SAV001 vaccine to prevent HIV infection by employing a genetically modified HIV-1 (nef-deleted, vpu-deleted, and Env signal peptide replaced) grown in human T-lymphocytes, inactivated by chemical (AT-2 treatment) and physical (γ irradiation) methods. We have completed Phase I human clinical trial of this vaccine in August, 2013 and we are currently preparing for the Phase II human trial. The Phase I human clinical trial results showed that the vaccine is completely safe in vaccinees and stimulated adaptive immune responses to generate antibodies against HIV-1 structural proteins. The Phase I trial results forecast a favorable outcome of the Phase II trial. This killed whole-HIV vaccine is a unique approach in HIV vaccinology. This approach will present the native structural proteins of HIV-1 to the immune system which strategy has proven effective for decades in the prevention of polio, influenza, rabies, hepatitis A, and more than 15 animal viral diseases. In addition to our prophylactic HIV-1 vaccine, we are also developing a therapeutic vaccine to clear HIV-1 infected cells in HIV-1 positive people using two antigenically distinct genetically modified vesicular stomatitis viruses vectors carrying HIV-1 structural protein genes. HIV-1 gag, pol and env genes were inserted into genetically modified VSVInd and VSVNJ vectors. The HIV- 1 gag, pol, and env were expressed efficiently and processed properly in cells infected with rVSV-HIV viruses. Priming with rVSVIND-HIV virus and boosting with rVSVNJ-HIV virus induced high levels CD8 + CTLs and produced antibodies against Gag and Env proteins. Our results showed that genetically modified dual serotype VSV vectors, carrying HIV-1 structural genes expressed high levels of HIV-1 structural proteins and induced robust adaptive immune responses in mice. This platform technology can be applied for therapeutic HIV vaccine development and is also applicable for other vaccines
Biography
Chil-Yong Kang, PhD, DSc, FRSC, is a Molecular Virologist and Professor of Virology in the Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry at Western University in Canada (1992-Present). He did his Undergraduate studies in both Korea and Denmark and was trained at University of Toronto and continued his Postgraduate studies at McMaster University where he received a PhD in Virology in 1971. His postdoctoral training was in the U.S. at the University of Wisconsin-Madison (1971-1974). He served as a Professor of Microbiology at the University of Texas, Southwestern Medical School in Dallas, Texas (1974-1982), Professor and Chairman of the Department of Microbiology and Immunology at University of Ottawa, Faculty of Medicine (1982-1992), and Dean of Science at the University of Western Ontario (Western University) (1992-1999). Previously, he developed a second generation vaccine against hepatitis B virus and an experimental vaccine against HIV/AIDS. He has published 135 peer reviewed research papers and 149 scientific proceedings and abstracts in fields of virology, immunology molecular biology, and medicine. He holds nine international biotechnology patents. He has received numerous prizes, was selected as one of four Korean-Canadian Diasporas to Canadian Society by Canadian Government (2013) and the Scientist of the Year Award of the President of the Korean Federation of Science and Technology (2013). He was elected as a Life-time Fellow of the Royal Society of Canada Academy of Science (1993) and an elected Life-time Member of the Korean Academy of Science and Technology (1997). He serves as a reviewer for the Journal of Virology, Journal of Infectious Diseases, Virus Research, Virology, Journal of Biological Chemistry and Canadian Medical Association Journal.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords