alexa Human IPS Cells Are An Alternative Source Of Pancreatic Beta Cells
ISSN: 2165-7092

Pancreatic Disorders & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd Intenational Conference on Pancreatic Disorders & Treatment
September 13-14, 2017 Dallas, USA

Nicholas Zavazava
University of Iowa, USA
Keynote: Pancreat Disord Ther
DOI: 10.4172/2165-7092-C1-004
Abstract
Type 1 diabetes (T1D) is caused by autoimmunity whereby pancreatic beta cells are destroyed by autoimmune disease. Standard therapy is replacement of insulin by regular injections of recombinant insulin. However, T1D can be cured by the transplantation of pancreatic islets or that of the whole pancreas organ. Our approach is to generate iPS from the patient and derive pancreatic beta cells from those cells and transplant them back to the patient. The advantage of this approach is that we could potentially transplant patients early after diagnosis with no waiting times for the availability of organs and we would not require the use of immunosuppressant since the cells are self-derived. Fibroblasts from a healthy individual were transduced with the Yamanaka factors in a retroviral vector. After confirming that the cells were pluripotent, the cells were differentiated into the endoderm which co-expresses CXCR4 and Sox 17. Next the cells were exposed to growth factors that converted them into the foregut endoderm. The cells were further treated to form the pancreatic precursor cells which expressed Pdx1. After further treatment with GLP-1 and niconinamide, the cells formed pancreatic beta cells. These cells highly express GLP-1R and are responsive to high glucose by secretion of insulin. When transplanted in diabetic mice, they correct hyperglycemia within 3-4 weeks. Thus human iPS cells are an alternative source of pancreatic beta cells that can be harnessed for the treatment of diabetes.
Biography

Dr. Nicholas Zavazava is currently working as a Professor and Director of Transplantation Research at University of Iowa, USA. His work primarily focusses on stem cells. His lab is interested in studying stem cell derived hematopoietic cell and insulin producing cells.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version