alexa Human Vaccines Project: Decoding The Human Immune System To Accelerate Next Generation Vaccine Development
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

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16th Euro Global Summit and Expo on Vaccines & Vaccination
June 19-21, 2017 Paris, France

Wayne C Koff
Robert Wood Johnson Foundation, USA
Posters & Accepted Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560-C1-058
Abstract
Vaccines have been one of the most effective public health interventions over the last century, preventing and controlling a broad spectrum of infectious diseases. However, over the last 15 years there have been several failures in late stage vaccine and immunotherapeutic development programs, against viral, bacterial, parasitic and neoplastic diseases. These failures are due to the lack of understanding of the human immune system and reliance on empiric strategies for vaccine development that are unlikely to be effective in the future. The Human Vaccines Project (Project) is a nonprofit public-private partnership that has been established to accelerate development of next generation vaccines and immunotherapies for major global infectious and neoplastic diseases by decoding the human immune system. The project has created a unique model of engaging multinational pharmaceutical partners with key stakeholders from academia, governments and non-governmental organizations, into a human immunology-based, milestone driven, global research consortium. The project aims to decode the human immune system by establishing and following a series of decade long cohorts, varying by age, gender, ethnicity and geography, for deciphering the human “immunome”. This will include the repertoire of B and T cell receptors of the human immune system, and the immune targets recognized by antibodies and T cells for selected infectious and neoplastic diseases to facilitate vaccine discovery. The project also aims to elucidate the “rules of protective immunity” in humans by conducting strategic, small, iterative exploratory clinical research trials of licensed and experimental vaccines and immunotherapies to systematically solve the key problems impeding next-generation product development. Proposed pilot studies of the project aimed at assessing the human immunome and immune responses to vaccines across heterogeneous populations will be discussed.
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