alexa Ide Sequestration, Release And Ecology Of The Anticancer Drug Taxol From Fungal Endophytes
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Sameh Soliman
University of Guelph, Guelph, Canada
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
Taxol is produced by Taxus trees and their resident endophytic fungi. A mystery has been why these endophytes synthesize Taxol apparently redundantly. A defining feature of these trees is that they can propagate branches from long-lived buds that lie underneath the bark; branch emergence is accompanied by bark cracks, potential pathogen entry points. Here, we show that Taxol acts as a fungicide against wood decaying fungi (WDF) to which these long-lived trees are susceptible. Reducing endophytes in plants resulted in increased WDF growth. Endophytes sequestered Taxol in intracellular hydrophobic bodies (Hb), which prevented plant cytoxicity. Taxol-producing endophytes with these Hb localized to vascular rays within wood, but hyperaccumulated where the rays intersected branch points and associated air pockets. Chloromethane, a chemical released by WDF, along with chitin or WDF, induced Hb release from endophytes. Hb was released from endophytes by exocytosis; chloromethane induced exocytosis genes. Combined, Taxol-producing endophytes contribute to the survival of their host by protecting their nutrient-rich vascular system and branch points against systemic fungal pathogen invasion.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version