Embryonic stem (ES) cells and genetically modifi ed stem cells are being widely used in
basic research in the fi eld of regenerative medicine. However, clinical application of these
cells is currently diffi cult in view of ethical issues. On the other hand, cells derived from bone
marrow, adipose tissue or other tissues have attracted attention as clinically applicable sources
of autograft ing cells, because these cells can diff erentiate into various types of cells, including
adipocytes, osteocytes, chondrocytes, smooth muscle cells, endothelial cells and neuronal cells.
Since, adipose tissue yields mesenchymal stem cells (MSCs) 500 fold greater than bone marrow,
isolated with minimal invasive procedure and moreover, it is contaminated with lesser number
of hematopoietic stem cells, it could be a better source for mesenchymal stem cells. Surface
markers are now increasingly used for identifi cation of these cells and their diff erentiation.
Even these markers are being exploited for obtaining homogenous cell prearation. Many surface
antigens which are known for mouse bone marrow MSCs but their presence or absence in
mouse adipose tissue has not been established. Comparatively, identifi cation of markers on
adipose derived MSCs from human is actively pursued. So far, presence or absence of 36 well
studied surface markers on human adipose derived MSCs is established, albeit some of them
being doubtful. In contrast, presence of only 6 markers and absence of 10 markers in mouse
adipose derived MSCs has been established.
Ms. Vandana is pursuing PhD from National Dairy Research institute which is a premier institute of INDIA in
Dairy Research sector. She has completed Master of sciences from Maharshi Dayanad University, Rohtak,India.
She has a very good academic record and awarded Institute Fellowship from, Indian Council of Agricultural
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals