alexa Identification Of A Novel Target That Regulates Breast Cancer Stem Cells
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

10th International Conference on CANCER STEM CELLS AND ONCOLOGY RESEARCH
June 26-28, 2017 London, UK

Monther Al-Alwan
King Faisal Specialist Hospital and Research Centre, Saudi Arabia
ScientificTracks Abstracts: J Cancer Sci Ther
DOI: 10.4172/1948-5956-C1-102
Abstract
There have been significant advances in breast cancer treatment, which have been attributed to the use of targeted therapy in combination with surgery and chemotherapy. However, the tumor-related mortality remained high mainly due to chemoresistance resulting in relapse and metastasis. Chemoresistance is widely believed to be regulated by a small subpopulation of the tumor bulk that possess stem cell-like features and thus are called cancer stem cells (CSCs). We have shown significant association between worse clinical outcome in breast cancer patients, including metastasis and shorter survival, and expression of fascin, an actin-bundling protein. Moreover, we have also reported that fascin is a critical mediator of breast CSCs and chemoresistance, via the activation of focal adhesion kinase (FAK), which is known to directly bind members of the integrin adhesion molecules. Here we have used fascin loss and gain of function approaches to examine if fascin influences integrin expression to regulate breast CSC function. Our results have demonstrated that fascin expression in breast cancer cells is directly associated with increased expression of integrins including: CD49a, CD49C, CD49f, CD29 and CD61. Fascin-mediated integrin expression on breast cancer cells enhances their adhesion, chemoresistance and tumorsphere formation ability. This study supports a role for fascin in the maintenance of breast CSCs via the regulation of integrin expression. The outcome of this study is expected to provide another evidence that fascin targeting may present a new approach for optimal treatment of breast cancer from the root.
Biography

Monther Al-Alwan has completed his PhD in immunology from Dalhousie University and postdoctoral studies from University of Manitoba, Canada. He is a Scientist at the stem cell and tissue re-engineering program (SCTRP) at King Faisal Specialist Hospital and Research Centre and Adjunct Associate Professor at AlFaisal University, Riyadh, Saudi Arabia. Currently, he is actively involved in dissecting the molecular pathways that regulate the function of cancer stem cells and how this is related to chemoresistance and metastasis. He has more than 22 peer-reviewed publications in reputed journals and has been serving as an Editorial Board Member of various international journals.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

phar[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords