alexa Identification Of Inhibitors For The Lutheran - Laminin Interaction By Molecular Modeling Techniques To Reduce The Vaso-occlusive Crises Of Sickle Cell Disease
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Fabrice Gardebien
Université de la Réunion, France
ScientificTracks Abstracts: Med chem
DOI: 10.4172/2161-0444.C1.027
Abstract
Drepanocytosis is a genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. In the pathogenesis of vaso-occlusive crises of sickle cell disease, red blood cells bind to the endothelium and promote vasoocclusion. At the surface of these sickle red blood cells, the over-expressed protein Lutheran strongly interacts with the protein Laminin found on the endothelium. The aim of this study is to identify a protein-protein interaction inhibitor with a high probability of binding to Lutheran for the inhibition of the Lutheran-Laminin interaction. A virtual screening was performed with 395 601 compounds that target Lutheran. Prior validation of a robust docking and scoring protocol was considered on the protein CD80 because this protein has a binding site with similar topological and physico-chemical characteristics; CD80 also has a series of ligands with known binding affinity constants. The protocol that was finally selected consisted of multiple filtering steps based on docked scores, molecular dynamics simulations, post-screening scores, and molecular properties. We were able to identify promising compounds that could reduce the Lutheran-Laminin interaction as measured by our microfluidic platform capable of quantifying cell rolling and binding/adhesion.
Biography

Fabrice Gardebien has completed a PhD in Theoretical Chemistry from the University of Pierre and Marie Curie (Paris, France) and Postdoctoral studies from University of Mons (Mons, Belgium). He is interested in predicting protein-ligand interactions by combining molecular modeling techniques (molecular docking and molecular dynamics) and quantum chemistry (ab initio and semi-empirical levels). He is the Director of the DSIMB team based in Reunion Island.

Email: [email protected]

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