alexa Identification, Optimization, Designing And Synthesis Of Drug-like Heterocyclic Templates For The Treatment Of Type II Diabetes Mellitus | 71194
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Joint Event: 3rd International Conference on Biopharmaceutics and Biologic Drugs & 5th International Pharmacy Conference

Gajjar Krishna and Gajjar Anuradha
Nirma University, India
RPCP Charusat, India
ScientificTracks Abstracts: J Bioequiv Availab
DOI: 10.4172/0975-0851-C1-030
Abstract
Free fatty-acid receptor 1, is a G-protein-coupled receptor that binds long chain free fatty acids to enhance glucose-dependent insulin secretion and are therefore viable targets for diabetes and metabolic disorders. In the course of the research work, QSAR study, Pharmacophore generation, Molecular Docking, in-silico ADME studies and synthesis was performed to explore the molecular determinants responsible for the agonist action at GPR40. The generation of ligand & structure based pharmacophore using the standard tools within Catalyst from different training sets consisted of Hydrophobic, Hydrogen Bond Acceptor and Aromatic ring features as essential aspects. The most representative features were selected and included in the pharmacophore model which was further validated and utilized as a query tool to search 3D databases. CoMFA, CoMSIA and HQSAR were performed on series of 3-aryl-3-ethoxypropanoic acid derivatives to build 3D-QSAR models. Contour maps provided significant insights which gave hints for the modification required to design new molecules with improved biological activity. Molecular docking studies were carried out on designed molecules using Sybyl-X software. Out of these the best Heteroaryl systems, specifically the five membered pyrazole ring system was being explored and some of the virtual structures were synthetically explored, and 3-[3-(4-methoxyphenyl)-4-(phenoxymethyl)-1H-pyrazol-1-yl] acetic acid derivative class of compounds were synthesized taking into the account of sustainability and feasibility of the chemistry, which may act as a starting point for the in-house discovery program.
Biography

Krishna Gajjar is a Pharma Student, having Bachelors and Master degree in Pharmacy and currently pursuing PhD as Research Fellow (in Pharmaceutical Sciences- specialization in Medicinal Chemistry) from Nirma University, Ahmedabad, (Gujarat) India, under the guidance of Prof. Anuradha K. Gajjar.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7