alexa IL-33 Stimulation Down-regulated ADAMTS15 Gene And Protein In U118 Glioblastoma Cell
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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14th World Congress on Neurology and Neurological Disorders
July 17-18, 2017 Chicago, USA

Nezihe Asli Bayram
Suleyman Demirel University, Turkey
Posters & Accepted Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562-C1-056
Abstract
ADAMTS (A disintegrin-like and metalloproteinase domain with thrompospondin-1 repeats) are a large family of proteoglycanase that show proteolytic activity towards proteoglycans like aggrecan, brevican, neurocan and versican. Interleukin-33 (IL-33) is an IL-1 cytokine family member that uniquely play a role as a cytokine and nuclear factor. It is released by necrotic epithelial cells and activated innate immune cells as an alarming danger signal. ADAMTS and IL-33 implicated in brain cancer pathogenesis. We aimed to seek the amount of ADAMTS15 in U118 glioblastoma cell line which was stimulated by IL-33. Western blot and Real-time PCR methods were used. IL-33 treatment decreased ADAMTS15 protein and mRNA amount significantly. Therefore, ADAMTS15 potentially has a role in glioblastoma pathobiology.
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