alexa
Reach Us +1-947-333-4405
Immune Complex As Vaccines Against Tuberculosis | 37774
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

8th Indo Global summit and Expo on Vaccines, Therapeutics & Healthcare

Shakila H1, Sam Ebenezer1 and Gupta U D2
1Madurai Kamaraj University, India 2National JALMA Institute for Leprosy and other Mycobacterial Diseases, India
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.C1.033
Abstract
Immune complex (IC) is formed as a result of specific reaction between antigen and its specific antibody. Following the formation of these antigen-antibody complexes a cascade of events like opsonization, complement activation, antigen presentation occurs inside the host system. For many decades, either antigen or antibodies are being used as vaccine candidates. In the event of acquiring this kind of artificial immunization, involvement of humoral immunity is essential for memory response. But before that, the administered antigen has to be captured by cell mediated immune surveillance and has to be presented by APCs and this is a long time process. This kind of delay is avoided when preformed IC is administered, which directly binds with APCs through antibody mediated binding. Also Fc region of immunoglobulin from IC acts as molecular adjuvants and thereby enhances immunization position of IC. In a study by Wen et al., (1999) excess Hepatitis B surface antigen (HBsAg) complexed with human anti-HBs immunoglobulin was used as a therapeutic vaccine to treat chronic hepatitis B patients. Promising results were obtained and the studies indicated that IC induced enhanced immune responses by increasing the uptake of HBsAg through the Fc receptors on the antigen-presenting cells and modulating the HBsAg processing and presentation. In our preliminary study using preformed IC of tuberculosis, we observed a protective response in animals when administered with ICs of antigen excess. This showed a significant response when compared to the animals injected with antibody excess or without any ICs. Hence IC in future could be considered as efficient vaccine candidates for Tuberculosis.
Biography

Shakila H has completed her PhD from The Tamil Nadu Dr. MGR Medical University, Chennai and Post-doctoral studies from Tuberculosis Research Centre (ICMR), Chennai. She is the Associate Professor in the Dept., of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai, Tamil Nadu, India. She has published more than 20 papers in reputed journals and has been serving as Life Member in many societies and also Editorial Board Member of reputed journals till 2011. She has also reviewed many manuscripts in journals. Her area of research is immunology and immunopathology of infectious diseases like TB and HIV.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

https://www.gaziantepescort.info

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version