Immunohematopoietic Modulation By The Alga Chlorella In Obese Mice | 19599
Journal of Clinical & Cellular Immunology
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Investigation of modulating effects of Chlorella on the medullar and extramedullar hematopoiesis and cytokine
production of obese mice.
For the study of interaction between stromal cells and hematopoietic progenitor cells by long-term bone marrow
culture. Growth and differentiation of bone marrow and spleen progenitors (CFU-GM) were studied by clonal culture.
Cytokines were determined by ELISA.
In obese mice reduced capacity of stromal cell layer to support CFU-GM, decreased numbers of total non-adherent
stromal cells, increased levels of IL-1, IL-6, TNF-alfa, TGF-beta, reduced levels of IL-10, and extramedular hematopoiesis were
observed. This latter finding is pioneer in the literature and might be related to the accumulation of macrophage in adipose
tissue, a common feature in human and experimental obesity, which is considered responsible for the majority of complications
observed in this disease. CV treatment restored all these changes to normal values.
Additional findings, already published were also pioneer in literature showing that prevention by CV of high-fat
diet-induced insulin resistance in obese mice is due to improvement in insulin signaling pathway by increasing phosphorylation
levels of IR, IRS-1 and Akt and reducing phosphorylation levels of IRS-1ser307. It was also found that CV prevents high-fat
diet-induced dyslipidemia by reducing triglyceride, cholesterol and free fatty acid levels. Altogether the findings suggest that
prevention by CV of the deleterious effects induced by high-fat diet is a good indicator for its use as a prophylactic agent against
Mary L S Queiroz has completed her PhD from the University of Manchester, England, and her Postdoctoral studies from WEHI, Melbourne, Australia. She is
a Full Professor, Director of the Laboratory of Immunopharmacology, Medical Faculty, UNICAMP, Campinas, Brazil. She has published more than 80 papers in
reputed journals and presented several pioneer and original results in the literature, starting with the focus of her studies on the modulation by medicinal plants of
immunohematopoietic regulatory mechanisms, aiming to increase or restore the host's own defenses which can inhibit infectious and malignant processes.
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