alexa Immunohistochemical Analysis Of PTEN, HER2/neu And Ki-67 Expression In Patients With Gastric Cancer And Their Association With Survival
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Cytopathology & Histopathology
June 21-22, 2017 Philadelphia, USA

Dalia Mohmmed Mohsen Badary
Assuit University, Egypt
Posters & Accepted Abstracts: J Cytol Histol
DOI: 10.4172/2157-7099-C1-012
Abstract
Background & Aim: Considering the poor prognosis of patients with gastric cancer, molecular diagnostic and prognostic markers for this cancer should be established. The aims of our study were to assess the correlations between expressions of PTEN, HER2/neu and Ki-67 and various clinicopathological factors, as well as their influence on OS and DFS. Patients & Methods: In this descriptive-analytic study, 42 patients with gastric carcinoma treated by postoperative chemoradiation between January 2004 and January 2014. Pathological review was done for pathological staging. Immunohistochemical staining (using the avidin biotin immunoperoxiase complex technique) and evaluation (with the assis┬Čtance of a histopathologist) were performed. Results: All the studied markers were significantly correlated with pathological T stage and increased TNM stage. In addition, Her2/neu overexpression and positive Ki-67 expression were significantly associated with histological grade. High percentage of positive Her2/neu and Ki-67 expression was found in gastric carcinoma tissue samples which lack PTEN expression. One-year OS rate for the entire group (n=42) was 77.4%, whereas the DFS rate was 45%. Pathological T stage PTEN status significantly affected both OS (p=0.029 and 0.027 respectively) and DFS (p=0.006 and 0.012 respectively) rates. Multivariate Cox analyses showed that only pathological T stage was independent prognostic factor affecting OS (P=0.007, HR: 2.02; 95% CI: 1.2-3.38) and DFS (P<0.0001, HR: 2.69; 95% CI: 1.54-4.69). Conclusion: All the studied molecular markers were significantly correlated with pathological T stage that significantly affected both OS and DFS rates.
Biography

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords