alexa Immunological Aspects Of PCOS: The Road Less Travelled
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

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2nd World Congress on Polycystic Ovarian Syndrome
October 05-07, 2016 Orlando, Florida, USA

Dimitrios Kafetzis
Assisted Reproduction and Gynaecology Centre (ARGC), UK
Posters & Accepted Abstracts: Endocrinol Metab Syndr
DOI: 10.4172/2161-1017.C1.015
Abstract
Despite the significant progress made over the past decades towards defining the exact aetiology of polycyctic ovaries, we are still not in a position to offer a plausible and life changing solution to women with PCOS (Polycystic Ovary Syndrome). Anovulation, subfertilty, pregnancy loss, weight control, hirsutism and diabetes keep affecting their quality of life, making PCOS a global problem. The scientific community has not focused on the immunogical side of PCOS until only a few years ago. Yet strong evidence is immunological factors that may be playing a significant role in the pathogenesis of the syndrome, and there is now enough studies to demonstrate that women with PCOS have increased circulatory levels of inflammatory cytokines, reduced T regulatory cell levels and higher risk of subclinical thyroidism. There are also studies to suggest that this immunological disregulation seen in women with PCOS affects early angiogenesis at the level of the decidua, a connection that could shed light to the higher risk of first trimester pregnancy loss experienced by PCOS patients. This presentation attempts to “join the dots” between current studies on Immunology of PCOS and everyday clinical practice and broaden the horizons of Ob/Gyns and REIs with consice and practical advice for the management of PCOS patient beyond the standard and unfortunately largely inefficient current care.
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