alexa
Reach Us +1-504-608-2390
Immunomdulatory Effects Of Probiotics And Prebiotics On Immune System During (DSS)-induced Experimental Colitis | 19688
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Clinical & Cellular Immunology

Ryma Toumi, Katia Abdelouhab, Hayet Rafa, Imene Soufli and Chafia Touil-Boukoffa
Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.019
Abstract
Introduction: The inflammatory bowel diseases (IBDs), represented mainly by ulcerative colitis and Crohn disease refer to chronic and relapsing disorders that affect the gastrointestinal tract. Studies have indicated that these diseases result from a lack of tolerance to resident intestinal bacteria in genetically susceptible hosts. It seems that in IBD the mucus barrier is broken. The production of high levels of the nitric oxide (NO) by the inflammatory cells plays a part in tissue injury; in the current study, we investigate the potential preventive effects of inulin on dextran sulphate sodium (DSS)-induced experimental colitis in Swiss albino mice. Methods: The colitis was induced in mice via administration of 2.5% DSS in drinking water for 7 days. During this period the Swiss albino mice were given 1% (w/v) inulin in their drinking water ad libitum for 7 days. The production of NO was evaluated in the supernatants of peritoneal macrophages (pMφ) cultures. The mucus production by the goblet cells in the colon was determined. Results: A significant shortening of colon length was observed and high levels of NO in pMφ cultures were observed in DSS group compared to control. Oral administration of inulin decreased the severity of DSS-induced colitis. NO production in pMφ supernatants was lower in inulin group and correlated with a reduction of colonic lesions. Conclusion: The prebiotic inulin improved DSS-induced colitis symptoms by down regulation of NO production and induction of mucus secretion. Prebiotics seem to be promising for development of preventive strategies approach for IBD using dietary supplementation .
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

streamtajm

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version