alexa Impact Of Novel Lipidized Analogs Of Neuropeptides On Food Intake Decrease And Metabolic Changes In Rodents
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Endocrinology
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Lenka Maletinska
ScientificTracks Abstracts: Endocrinol Metab Synd
DOI: 10.4172/2161-1017.S1.005
Abstract
Obesity is a frequent metabolic disorder but an effective therapy is still scarce. Anorexigenic neuropeptides seem to be potential specific tools for obesity treatment but their peptide character complicates their delivery to the brain, necessary for their central effect, and makes them subjects of fast degradation. In order to overcome the unfavorable facts mentioned, lipidization of anorexigenic neuropeptide prolactin-releasing peptide (PrRP) whose strong anorexigenic effect was demonstrated with the fact that both PrRP and its receptor knock-outs resulted in obese phenotypes, was applied. Analogs of PrRP with attached fatty acids showed unabated biological activities compared to the native PrRP regarding binding affinity and signaling in cells expressing PrRP receptor. Most interestingly, these analogs revealed a strong and long-lasting anorexigenic effects after their peripheral administrations to fasted mice and rats and neuronal activation in brain areas involved in food intake regulation. Moreover, repeated subcutaneous administration of palmitoylated PrRP lowered food intake and body weight and improved metabolic parameters in diet-induced obese mice. For the anorexigenic effect of native PrRP, central administration was necessary. Lipidization of PrRP enabled its peripheral administration for its anorexigenic effect in the brain, most probably by enhancing its stability in the blood and mediating the peptide to cross the blood brain barrier.
Biography
Lenka Maletinska received her PhD from the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic and her post-doc training from University of Sherbrooke, Quebec, Canada and Lawrence Berkeley Laboratories, Berkeley, California. Recently, she is the head of the group Antiobesity peptides at the Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic. Her research interests focus on peptides involved in food intake regulation and mechanisms of their action. She published over 40 articles in peer-reviewed journals. She is a member of European and American Peptide Society and editorial board member of JOE and JME.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version