alexa Impacts Of Previously Established Loci Associated With Obesity-related Traits On Type 2 Diabetes
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
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2nd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
November 03-05, 2014 Embassy Suites Las Vegas, USA

Joo-Yeon Hwang, Juyoung Lee and Bong-Jo Kim
Posters: J Pharmacogenomics Pharmacoproteomics
DOI: 10.4172/2153-0645.S1.003
Abstract
To date, genetic predispositions to type 2 diabetes (T2D) underlying obesogenic environments have demonstrated genetic heterogeneity across global populations. To extend understanding of the overall genetic architecture, we recapitulated previous obesity-related susceptibility loci on T2D risk in two ethnic-different consortiums (the DIAGRAM and the AGENT2D). A total of 64 SNPs in or near 41 genes were observed with pleiotropic associations on T2D (9 trans-ethnic, 22 Europeanspecific and 10 Asian-specific). In a conditional analysis, 14 genes were found to be associated with T2D risk in obesityindependent manner. In conclusion, our findings might expand understanding of multiple genetic effects in metabolic and endocrine regulation.
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