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he repair of large segmental bone defects due to trauma, inflammation and tumor surgery remains a major clinical problem.
There have been several attempts to combine bioactive glasses (BaGs) with biodegradable polymers to create a scaffold
material with excellent biocompatibility, bioactivity, biodegradability and toughness .Mesenchymal stem cells (MSCs) are defined
as non-hematopoietic cells that are able to replicate for a long time while maintaining their multilineage differentiation potential.
Rat MSCs were isolated from the femurs of rats. The bone marrow suspensions were cultured in the DMEM medium.
BG Nano-powders were synthesized and Gelatin / Bioactive glass nano-composite scaffold was made through Sol-Gel and
crosslinked by glutaraldehide treatment. The BG scaffolds were sterilized, to observe the cytotoxic effects of the BG scaffolds on
. The proliferation medium of the cultures will be replaced by osteogenic medium. Occurrence of differentiation
will be examined by alizarin red staining. Differentiated rMSCs seeded into scaffolds. Two bilateral full thickness defects created
in the calvarium of rats. The defects will be filled by nano bioglass scaffolds enhanced with differentiated rMSCs. Evaluation
will be performed using histology. Cellular toxicity test results revealed that BG scaffolds has no toxicity. Following alizarin red
staining, red mineralizing areas of cultures appeared and revealed that those cells differentiated to osteogenic cells. This research
studies have been shown that Nano bioglass scaffold could support MSCs proliferation and differentiation
study demonstrates that rMSCs enable bone reconstruction of calvarial defects in an allogenic transplantation model by nano
Afsaneh Amiri has completed her Ph.D. at the age of 25 years from Science and Research branch of Azad University in Tehran - Iran and postdoctoral
studies from Hallym University School of Medical Science in South Korea. She has been done her teaches and researches as a
in Central Tehran branch of Azad University for more than 15 years. She has published more than 20 papers in reputed journals
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