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In Silico Enzyme Selectivity Predictions Of Four Major Phase II Drug Metabolism Enzymes | 8015
ISSN: 2153-0769

Metabolomics:Open Access
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In silico enzyme selectivity predictions of four major phase II drug metabolism enzymes

International Conference and Exhibition on Metabolomics & Systems Biology

Hyoungjun Son and Kyoung Tai No

Posters: J Comput Sci Syst Biol

DOI: 10.4172/0975-0851.S1.10

The liver is the main site of drug metabolism in human body. Drug metabolism in liver, converting lipophilic substrates into more polar products which are easily excreted form, occurs in two steps, phase I and phase II. Especially, phase II metabolism is important because it is fast pathway for drug elimination and closely related with excretion, but still practical models are not available. Generally, phase II transformations conjugate a highly polar group to the substrates, then produce more hydrophilic products than its substrates. We categorized these metabolic reactions into four major classes. The reactions are glucuronidation, sulfation, N-acetylation and glutathione conjugation, and enzymes responsible for those reactions are UDP-glucoronosyl transferase (UGT), sulfotransferase (SULT), N-acetyltransferase (NAT) and glutathione transferase (GST) respectively. We made four in silico substrate classification models using random forest method. ECFP_4 is selected as molecular descriptor. ECFPs are topological fingerprints for molecular characterization using Morgan algorithm to capture molecular features. These models effectively predict phase II transformational fate of a drug molecule. And we also found that suggestion of important substructure features is possible by statistical analysis of random forest models.
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