alexa In Silico Study Of Lipids Associated In Non-bilayer Phospholipid Arrangements
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th European Immunology Conference
June 29-July 01, 2017 Madrid, Spain

Sanchez B Sandra, Landa S Carla E, Resendiz M Claudia A, Wong B Carlos, Wong R Carlos, Yanez M Cornelio, Castelan V Juan Arturo, Dominguez D Laura and Baeza R Ma Isabel
ENCB- The National Polytechnic Institute, Mexico
Computer Research Center-IPN, Mexico
National Autonomous University of Mexico, Mexico
Posters & Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899-C1-037
Abstract
Statement of the Problem: Systemic lupus erythematous (SLE) is an autoimmune, chronic and multifactorial disease. For SLE study, some animal models had been developed, and our lab has one. Our model was obtained by administering a different lipid bilayer structure called non-bilayer phospholipid arrangements. These non-bilayer phospholipid arrangements can be stabilized with drugs such as chlorpromazine or procainamide and specifically in female mice, causing a disease very similar to human SLE. To help understand how these lipid structures in the development of the disease involved, we used bioinformatics tools to understand how they form, and now we’ll try to extrapolate this to explain some of the symptoms faced by patients with SLE. Methodology & Theoretical Orientation: A molecular simulation was established using all the conditions used in our murine model with chlorpromazine and was created with GROMACS software. Analyses of results were made with GROMACS utilities, proprietary Python programs and VMD tools. Findings: With our simulation strategy, we were able to observe differences between diverse lipidic environments with one or various molecules of chlorpromazine. Also, we have started new simulations to improve our strategy and get more useful information for our molecular knowledge of the models and the etiology of the human disease. Conclusion & Significance: These findings help us to understand how the models are triggered and give us clues about how to improve them for a further research of how SLE is initiated in humans. That probably will contribute to the improvement of the models and support our novel theory about the etiology of the SLE disease in humans.
Biography

Sánchez B Sandra has her expertise in Molecular Biology and Bioinformatics, and is passionate about Biochemistry and Science Communication. Her novel approximation to the function of a drug on a bilayer membrane can help to better understand our murine models and how this can impact our knowledge on the systemic lupus erythematosus disease. She has built her abilities after years of experience in research, project administration and protocols development in the Pharmaceutical Industry, teaches of Biochemistry and Genetics for physicians, and translates pharmaceutical documents and participates in science fairs for kids. This work was possible due to her willingness to collaborate with external researchers, as Laura Domínguez from FQ-UNAM and Cornelio Yañez from CIC-IPN, who gave her the tools and knowledge to use bioinformatics and a Mexican Supercomputer to realize this project.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords