In vitro behavior of nurses A phasess, a new calcium silicophosphate ceramic for bone tissue engineering

3^rd International Conference and Expo on Ceramics and Composite Materials

June 26-27, 2017 Madrid, Spain

De Aza P N, Rabadan-Ros R, Mazon P, Serena S, Sainz M A and Meseguer-Olmo L

Universidad Miguel Hern�¡ndez, Spain
Universidad Cat�³lica San Antonio de Murcia, Spain
Instituto de Cer�¡mica y Vidrio, Spain

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

In the present study, a new single phase Si-Ca-P based ceramic (called Nurse�´s Ass) was obtained and it�´s in vitro behaviour for potential bone tissue regeneration was explored. Porous Si-Ca-P (Nurse�´s Ass) single phase ceramic was obtained from high temperature sintering of �³-dicalcium silicate and �²-tricalcium phosphate previously synthetized. The apatite-mineralization ability and dissolution rate have been systematically studied by immersion of the material in simulated body fluid (SBF) for several periods of time. A massive formation of a new dense calcium deficient hydroxyapatite (CDHA) layer was observed at the SBF-sample interface. Adjacent to the dense CDHA layer a porous structure has been developed parallel to the interface which is formed by pseudomorphic transformation of the Si-Ca-P (Nurse�´s Ass) into CDHA. In addition, cell attachment test showed that the new material supported the adult human bone marrow-derived mesenchymal stem cells (hMSCs) adhesion and spreading; the cells established close contact with the ceramic surface in an extended culture of 28 days (Figure 1). In view of the results, Nurse�´s Ass ceramic should be an effective substrate promoter of bone tissue regeneration suitable for bone tissue bioengineering. Future performance should be led using standard biomaterials, such as Si-HA or Si-TCP. The Nurse�´s Ass biological performance should be investigated as proposed in International Standard ISO-10993-5.

Biography :

De Aza P N studied Chemistry-Ceramics at the Santiago de Compostela University, where she received her Doctoral Degree in 1995. She did a Postdoctoral stage at the IRC in Biomaterials at the Queen Mary & Wetsfield College, University of London (UK) working on in vitro and in vivo behavior of Bioceramics. At this moment, she is the Chair of the Materials Science, Optic and Electronic Technology Department, Professor of Materials Science and Metallurgical Engineering and Researcher at the Bioengineering Institute at the Miguel Hernandez de Elche University.

Email: piedad@umh.es