Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Enik�? Borbás
ScientificTracks Abstracts-Workshop: J Pharma Care Health Sys
As most of the newly discovered active pharmaceutical ingredients (APIs) have poor water solubility, dissolution enhancement of the Biopharmaceutical Classification System (BCS) II type (poorly water-soluble, but highly permeable) drugs is one of the most pressing pharmaceutical challenges. For the evaluation of dissolution enhancement, dissolution tests are used in the industrial protocol. However, the results of these tests do not always correlate with the bioavailability. One common reason for the lack of correlation is that studying dissolution without permeability can be deceptive, since both of them have an impact on in vivo bioavailability. In addition, the solubility-permeability interplay cannot be overlooked in cases where the API is formulated to enhance its dissolution, because additives such as surfactants, polymers and cyclodextrins, can have an effect on the permeation of the drug molecules through the biological membranes. Our aim was to study electrospun formulation with μFlux, which is a novel technique that (by simultaneously measuring dissolution and permeability) has the potential to improve IVIVC (in vivo-in vivo correlation) and to reduce the number of experiments needed on animals. In the case of formulation screening, it could be a reproducible and cost-effective way of testing compared to cell-based or animal tests. Dosage forms produced by various formulation strategies could be investigated with this new analytical method.
Enik�? Borbás has completed her BSc from Budapest University of Technology and Economics. She has been awarded the Dennis Gabor award for young researchers in 2014. Her field of research is bioavailability enhancement of poorly water soluble drugs with electrospinning.