alexa In Vitro Screening And In Vivo Evaluation Of Hypoglycemic Potential Of Wrightia Tinctoria Seeds And Enterococcus Spp. In Alloxanized Diabetic Mice
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

16th Global Diabetes Conference & Medicare Expo
March 22-23, 2017 Rome, Italy

Mohsin Munawar, Najma Arshad, Ayesha Shahid and Syeda Aysha Raza
University of the Punjab, Pakistan
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.C1.064
Abstract
Herbal and probiotic treatments are one of important pharmacological strategies against diabetes mellitus. The present study was designed to evaluate the anti-diabetic potential of Wrightia tinctoria and Enterococcus spp. in alloxanized (150 mg/kg body weight) type II diabetic mice screened by various in vitro tests. To check in vivo efficacy, doses of W. tinctoria (200 and 400 mg/ml), Enterococcus spp. at concentration of CFU 1011 and combination of both were given to diabetic mice. A group treated with acarbose was also included as standard for comparison. In vitro results showed that methanolic extract Wrightia tinctoria seeds exhibited the inhibition of α-amylase activity (88.64% at 100 mg/ml), inhibition of hemoglobin glycosylation (88.4% at 3.56 mg/ml), and inhibitory effect on glucose uptake by yeast cell (91.62% at 500 mg/ml), while Enterococcus spp. presented glucose adsorption capacity (26.2%) at CFU 1011. In vivo evaluation showed protective effect of methanolic extract of W. tinctoria seeds and Enterococcus spp. towards serum glucose level and histological studies of pancreas in normal range as evidenced by following administration of extract and probiotic. Among all doses applied to alloxanized mice, W. tinctoria (400 mg/kg body weight) and combination of both W. tinctoria and Enterococcus spp. (200 mg/ml and 60 μl at concentration CFU 1011, respectively) showed the most significant reduction in blood glucose level which was almost equal to the standard drug acarbose. Moreover, they were not found to have any toxicological effect in liver function test, renal function test and lipid profile.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords