alexa In Vitro Screening And In Vivo Evaluation Of Hypoglycemic Potential Of Wrightia Tinctoria Seeds And Enterococcus Spp. In Alloxanized Diabetic Mice | 63684
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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16th Global Diabetes Conference & Medicare Expo

Mohsin Munawar, Najma Arshad, Ayesha Shahid and Syeda Aysha Raza
University of the Punjab, Pakistan
Posters & Accepted Abstracts: J Diabetes Metab
DOI: 10.4172/2155-6156.C1.064
Abstract
Herbal and probiotic treatments are one of important pharmacological strategies against diabetes mellitus. The present study was designed to evaluate the anti-diabetic potential of Wrightia tinctoria and Enterococcus spp. in alloxanized (150 mg/kg body weight) type II diabetic mice screened by various in vitro tests. To check in vivo efficacy, doses of W. tinctoria (200 and 400 mg/ml), Enterococcus spp. at concentration of CFU 1011 and combination of both were given to diabetic mice. A group treated with acarbose was also included as standard for comparison. In vitro results showed that methanolic extract Wrightia tinctoria seeds exhibited the inhibition of α-amylase activity (88.64% at 100 mg/ml), inhibition of hemoglobin glycosylation (88.4% at 3.56 mg/ml), and inhibitory effect on glucose uptake by yeast cell (91.62% at 500 mg/ml), while Enterococcus spp. presented glucose adsorption capacity (26.2%) at CFU 1011. In vivo evaluation showed protective effect of methanolic extract of W. tinctoria seeds and Enterococcus spp. towards serum glucose level and histological studies of pancreas in normal range as evidenced by following administration of extract and probiotic. Among all doses applied to alloxanized mice, W. tinctoria (400 mg/kg body weight) and combination of both W. tinctoria and Enterococcus spp. (200 mg/ml and 60 μl at concentration CFU 1011, respectively) showed the most significant reduction in blood glucose level which was almost equal to the standard drug acarbose. Moreover, they were not found to have any toxicological effect in liver function test, renal function test and lipid profile.
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