alexa Incidence, Severity And Outcome Of Acute Kidney Injury According To KDIGO Criteria Between Intensive Care Unit Patients
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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12th Global Nephrologists Annual Meeting
June 26-28, 2017 London, UK

Albana Gjyzari
University Hospital Center “Nene Tereza”, Albania
Posters & Accepted Abstracts: J Nephrol Ther
DOI: 10.4172/2161-0959-C1-040
Abstract
Objective: Aim of this study was to evaluate the incidence, severity and outcome of AKI in intensive care unit (ICU) patients according to KDIGO criteria. Materials & Methods: This retrospective cohort study, involved adult patients (≥18 years) admitted in two ICUs: The cardio-surgical and polyvalent ICU of a tertiary care hospital centre, between January 2007 and December 2007. Patients who stayed more than 24 hours were included. Transplanted and chronic dialysis patients before admission to the ICU were excluded. AKI was classified according to the KDIGO criteria using both serum creatinine and urine output (UO) criterion during their hospital stay. Demographic, severity scores of illness (SOFA score) on admission and outcome data were collected. Results: 382 ICU patients were included for the study. According to the KDIGO criteria 176 (46.1%) patients met criteria for AKI during the study period and were classified as non AKI 53.9%, stage I 24.6%, stage II 12.8%, and stage III 8.6%. AKI patients were aged, 60.5±12 years vs. non AKI patients 52.2±16 years; p<0.001 and had higher SOFA score: AKI 6.4±3.5 vs. non AKI 3±2, p<0.001. Male AKI patients were significantly more than non AKI 67% vs. 54.4% p=0.012. Recovery of renal function worsened with the progression of KDIGO stage: stage I 71.3%, stage II 38.8% and stage III 9.1%; p<0.001. Renal replacement therapy (hemodialysis) was used in 1.6% patients. Overall in-hospital mortality was 14.4%. Mortality according to the groups was: non AKI patients 4.4%; stage I 12.8%, stage II 18.4%, stage III 75.8%; p<0.001. Kaplan-Meier curve for ICU survival by KDIGO stage with Cox regression analysis was statistically significant, p<0.001 (Figure 1). Conclusion: High incidence of AKI according to KDIGO criteria was found between ICU patients. Even small changes of renal function are associated with significant worse outcome.
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